Consumption of a fermented dairy beverage improves hippocampal-dependent relational memory in a randomized, controlled cross-over trial

Cannavale, Corinne N.; Mysonhimer, Annemarie R; Bailey, Melisa A; Cohen, Neal J.; Holscher, Hannah D.; Khan, Naiman A.

doi:10.1080/1028415x.2022.2046963

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…as well as microbial functional profile [53]. On the other hand, in a recent intervention study, consumption of 6 servings per day of various fermented foods elicited changes in the microbial diversity and immune system [49] and in another recent study, daily consumption of 8 oz of a fermented dairy beverage increased Lactobacillus abundance and resulted in improvements in relational memory [12]. Similarly, a high fiber intervention of 40-50 grams of fiber per day (which is 10-15 grams higher than the fiber consumed in this study and than the recommended intake in various countries) specifically increased fiber degrading bacteria such as Bifidobacterium or Lactobacillus [54].…”

Section: Discussionmentioning

confidence: 98%

“…Leveraging this fundamental link between diet and the microbiota, emerging studies are also focusing on the impact of supplementation with single food items (e.g., whole fruits or vegetables or fermented foods), demonstrating some promising results in modulating microbiome-host interactions [11,12]. While such approaches are important in advancing our understanding of how a specific food impacts human microbiota and health and could lead to the discovery of new functional foods, humans consume a combination of food groups with every meal and studying single foods could overlook the potential synergistic effect dietary components might have, not just on overall health, but also on microbiota diversity and composition [13].…”

Section: Introductionmentioning

confidence: 99%

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Feed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population

et al. 2022

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The impact of diet on the microbiota composition and the role of diet in supporting optimal mental health have received much attention in the last decade. However, whether whole dietary approaches can exert psychobiotic effects is largely understudied. Thus, we investigated the influence of a psychobiotic diet (high in prebiotic and fermented foods) on the microbial profile and function as well as on mental health outcomes in a healthy human population. Forty-five adults were randomized into either a psychobiotic (n = 24) or control (n = 21) diet for 4 weeks. Fecal microbiota composition and function was characterized using shotgun sequencing. Stress, overall health and diet were assessed using validated questionnaires. Metabolic profiling of plasma, urine and fecal samples was performed. Intervention with a psychobiotic diet resulted in reductions of perceived stress (32% in diet vs. 17% in control group), but not between groups. Similarly, biological marker of stress were not affected. Additionally, higher adherence to the diet resulted in stronger decreases in perceived stress. While the dietary intervention elicited only subtle changes in microbial composition and function, significant changes in the level of 40 specific fecal lipids and urinary tryptophan metabolites were observed. Lastly, microbial volatility was linked to greater changes in perceived stress scores in those on the psychobiotic diet. These results highlight that dietary approaches can be used to reduce perceived stress in a human cohort. Using microbiota-targeted diets to positively modulate gut-brain communication holds possibilities for the reduction of stress and stress-associated disorders, but additional research is warranted to investigate underlying mechanisms, including the role of the microbiota.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Feed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population

et al. 2022

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“…In healthy young individuals (under 30 years), cognitive performance did not change significantly after 8 weeks of pre–probiotic supplementation [ 28 , 29 ]. Although, a study with a low sample size ( n = 26) involving healthy young adults (25–45 years), conducted by Cannavale CN et al [ 30 ], reported a significant improvement in relational memory after the participants consumed a fermented probiotic beverage for 4 weeks ( p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Fekete,

Lehoczki,

Major

et al. 2024

Nutrients

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Recent research exploring the relationship between the gut and the brain suggests that the condition of the gut microbiota can influence cognitive health. A well-balanced gut microbiota may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, and symbiotics are nutritional supplements and functional food components associated with gastrointestinal well-being. The bidirectional communication of the gut–brain axis is essential for maintaining homeostasis, with pre-, pro-, and symbiotics potentially affecting various cognitive functions such as attention, perception, and memory. Numerous studies have consistently shown that incorporating pre-, pro-, and symbiotics into a healthy diet can lead to improvements in cognitive functions and mood. Maintaining a healthy gut microbiota can support optimal cognitive function, which is crucial for disease prevention in our fast-paced, Westernized society. Our results indicate cognitive benefits in healthy older individuals with probiotic supplementation but not in healthy older individuals who have good and adequate levels of physical activity. Additionally, it appears that there are cognitive benefits in patients with mild cognitive impairment and Alzheimer’s disease, while mixed results seem to arise in younger and healthier individuals. However, it is important to acknowledge that individual responses may vary, and the use of these dietary supplements should be tailored to each individual’s unique health circumstances and needs.

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“…It was further inferred that the stress-alleviating effect of the intervention is dose-dependent [ 174 ]. Several other studies in healthy adults investigated the impact of dietary interventions and high-fibre, fermented foods on microbial diversity and the immune system and demonstrated profound changes in microbial diversity, increased abundance of Lactobacillus and Bifidobacterium, and reduced inflammatory markers [ 205 , 206 , 207 ]. These studies substantiate the influence of diet on gut microbial diversity and mental health, thus making it an ideal target for preventing MDD.…”

Section: A Conceptual Framework Of Probiotics Aligned To Precision Ps...mentioning

confidence: 99%

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

Johnson

Letchumanan

Thum³

et al. 2023

Nutrients

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Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents a key domain of healthcare, which currently has limited, adverse-effect prone treatment options, and probiotics may hold the potential to be a novel, customizable treatment for depression. Clinical depression is a common, potentially debilitating condition that may be amenable to a precision psychiatry-based approach utilizing probiotics. Although our understanding has not yet reached a sufficient level, this could be a therapeutic approach that can be tailored for specific individuals with their own unique set of characteristics and health issues. Scientifically, the use of probiotics as a treatment for depression has a valid basis rooted in the microbiota-gut-brain axis (MGBA) mechanisms, which play a role in the pathophysiology of depression. In theory, probiotics appear to be ideal as adjunct therapeutics for major depressive disorder (MDD) and as stand-alone therapeutics for mild MDD and may potentially revolutionize the treatment of depressive disorders. Although there is a wide range of probiotics and an almost limitless range of therapeutic combinations, this review aims to narrow the focus to the most widely commercialized and studied strains, namely Lactobacillus and Bifidobacterium, and to bring together the arguments for their usage in patients with major depressive disorder (MDD). Clinicians, scientists, and industrialists are critical stakeholders in exploring this groundbreaking concept.

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Consumption of a fermented dairy beverage improves hippocampal-dependent relational memory in a randomized, controlled cross-over trial

Cited by 9 publications

References 33 publications

Feed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population

Feed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

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