Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection

Maki, Kevin C.; Kaspar, Kerrie L.; Khoo, Christina; Derrig, Linda; Schild, A. L.; Gupta, Kalpana

doi:10.3945/ajcn.116.130542

Cited by 93 publications

(67 citation statements)

References 39 publications

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“…This reduction corresponded to a reduction of nearly half the frequency of cystitis in the first 3 months (46.2%) and an incidence ratio of 0.59 compared to placebo. This finding is comparable to the incidence ratio calculated in the Cochrane review [12] in 2008 based on 10 clinical studies (relative risk [RR] 0.65, 95% CI 0.46-0.90) [13] and also comparable to the recent Maki et al [14] study (RR 0.62, 95% CI 0.42-0.92). Another meta-analysis of 13 trials postponed the protective effect of cranberry consumption against recurrence of cystitis by 0.53 (95% CI 0.33-0.83) [15].…”

Section: Discussion/conclusionsupporting

confidence: 74%

“…We found no other references to this clinically important improvement. Maki et al [14] who investigated the time to first recurrence did not showed such results. The results of in vitro and in vivo studies suggest that cranberry interferes with the adherence of uropathogenic E. coli to the epithelial cells of the bladder, periurethral region, and intestinal tract [17][18][19][20].…”

Section: Discussion/conclusionmentioning

confidence: 81%

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A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (Vaccinium macrocarpon) (DUAB®) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis

Bruyère¹,

Azzouzi²,

Lavigne³

et al. 2019

Urol Int

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Objectives: The purpose of the study was to compare the efficacy of a product containing cranberry and propolis (DUAB) to placebo for reducing frequency of cystitis in women with recurrent acute cystitis. Method: A multicenter, placebo-controlled, randomized study of women aged >18 years with at least 4 episodes of cystitis in the previous 12 months was performed. The number of cystitis episodes over a 6-month follow-up was the primary end point. Results: Forty-two women were included in the cranberry + propolis group, and 43 women were in the placebo group. The mean age was 53 ± 18 years, with 6.2 ± 3.6 cystitis episodes in the previous year, with no differences between the 2 groups. The mean number of infections was lower in the propolis + cranberry group (respectively, 2.3 ± 1.8 vs. 3.1 ± 1.8). The total number of cystitis episodes in the first 3 months was lower in the propolis + cranberry group (0.7 ± 1.1 vs. 1.3 ± 1.1, p = 0.0257) after adjusting for water consumption. The mean time to onset of the first urinary tract infection (UTI) was also significantly longer in the propolis + cranberry group (69.9 ± 45.8 days vs. 43.3 ± 45.9, p = 0.0258). Tolerance to the treatments was good and comparable in both groups. Conclusions: We demonstrate for the first time that cranberry and propolis supplementation significantly reduces the incidence of UTIs during the first 3 months and delays the onset of an episode of cystitis.

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Section: Discussion/conclusionsupporting

confidence: 74%

Section: Discussion/conclusionmentioning

confidence: 81%

A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (Vaccinium macrocarpon) (DUAB®) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis

Bruyère¹,

Azzouzi²,

Lavigne³

et al. 2019

Urol Int

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“…Several clinical trials have showed the beneficial effects of cranberry intake on human health [1,2,3,4,5,6,7]. However, while in vitro studies have shown dose-response effects of cranberry (poly)phenols on the inhibition of microbial invasion of gut and bladder epithelial cells [8,9] and in the cytotoxicity of ovarian cancer cells [10], very few human dose-response studies have been conducted.…”

Section: Introductionmentioning

confidence: 99%

Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability

et al. 2017

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The beneficial health effects of cranberries have been attributed to their (poly)phenol content. Recent studies have investigated the absorption, metabolism and excretion of cranberry (poly)phenols; however, little is known about whether they follow a dose response in vivo at different levels of intake. An acute double-blind randomized controlled trial in 10 healthy men with cranberry juices containing 409, 787, 1238, 1534 and 1910 mg total (poly)phenols was performed. Blood and urine were analyzed by UPLC-Q-TOF-MS. Sixty metabolites were identified in plasma and urine including cinnamic acids, dihydrocinnamic, flavonols, benzoic acids, phenylacetic acids, benzaldehydes, valerolactones, hippuric acids, catechols, and pyrogallols. Total plasma, but not excreted urinary (poly)phenol metabolites, exhibited a linear dose response (r2 = 0.74, p < 0.05), driven by caffeic acid 4-O-ß-d-glucuronide, quercetin-3-O-ß-d-glucuronide, ferulic acid 4-O-ß-d-glucuronide, 2,5-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, ferulic acid, caffeic acid 3-O-ß-d-glucuronide, sinapic acid, ferulic acid 4-O-sulfate, 3-hydroxybenzoic acid, syringic acid, vanillic acid-4-O-sulfate, (4R)-5-(3′-hydroxyphenyl)-γ-valerolactone-4′-O-sulfate, 4-methylgallic acid-3-O-sulfate, and isoferulic acid 3-O-sulfate (all r2 ≥ 0.89, p < 0.05). Inter-individual variability of the plasma metabolite concentration was broad and dependent on the metabolite. Herein, we show that specific plasma (poly)phenol metabolites are linearly related to the amount of (poly)phenols consumed in cranberry juice. The large inter-individual variation in metabolite profile may be due to variations in the gut microbiome.

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“…The antiadhesion effect of cranberry is attributed to its high molecular mass constituents (Sobota 1984;Ofek et al 1996;Burger et al 2000;Weiss et al 2002). Likewise, many recent clinical studies proved the efficiency of cranberry in prevention of UTIs (Maki et al 2016;Fu et al 2017;Nabavi et al 2017;Thomas et al 2017). This study did not report bactericidal activity towards planktonic ( inflating the balloon, were evaluated.…”

Section: Discussionmentioning

confidence: 99%

Antibiofilm properties of triclosan with EDTA or cranberry as Foley Catheter lock solutions

et al. 2019

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Aims To investigate the efficiency of triclosan, ethylenediaminetetraacetic acid (EDTA) and cranberry alone or in combinations against Escherichia coli strains as urinary catheter lock solutions to reduce catheter‐associated urinary tract infections. Methods and Results Viable counting was used to assess antibiofilm activities for triclosan, EDTA and cranberry alone or in combinations against E. coli strains embedded in biofilm onto all‐silicon Foley catheter surface. The results revealed that combination of triclosan (10 mg ml−1/EDTA 30 mg ml−1) when filling the catheter balloon was able to eradicate and prevent biofilm formation among all tested E. coli including the resistant strains, whereas triclosan (8·5 mg ml−1)/ cranberry (103 mg ml−1) combination was a successful catheter lock solution by preventing all tested strains from adhering onto catheter surface when filled via the eye hole. Conclusions The combinations of triclosan/EDTA and triclosan/cranberry were significantly effective in eradicating and preventing biofilm formation of the tested E. coli strains on Foley catheters. Significance and Impact of the Study Combinations of triclosan/EDTA and triclosan/cranberry have a promising application as nonantibiotic catheter lock solution.

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Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection

Abstract: The consumption of a cranberry juice beverage lowered the number of clinical UTI episodes in women with a recent history of UTI. This study was registered at clinicaltrials.gov as NCT01776021.

Cited by 93 publications

References 39 publications

A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (<b><i>Vaccinium macrocarpon</i></b>) (DUAB®) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis

A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (<b><i>Vaccinium macrocarpon</i></b>) (DUAB®) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis

Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability

Antibiofilm properties of triclosan with EDTA or cranberry as Foley Catheter lock solutions

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