Consumption and ocurrence of antidepressants (SSRIs) in pre- and post-COVID-19 pandemic, their environmental impact and innovative removal methods: A review

Díaz-Camal, Nidya; Cardoso-Vera, Jesús Daniel; Islas-Flores, Hariz; Gómez-Oliván, Leobardo Manuel; Mejía-García, Alejandro

doi:10.1016/j.scitotenv.2022.154656

Cited by 65 publications

(53 citation statements)

References 106 publications

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“…The majority of the OECD (Organization for Economic Cooperation and Development) countries showed an increasing trend in their consumption since 2000, with Iceland reporting the most significant increase, which has doubled the average of all OECD countries, followed by Australia, Portugal and Canada (Sehonova et al, 2018). Furthermore, after the entry into force of the social measures linked to the COVID pandemic, a considerable increase on the prescription of these drugs has been detected (Diaz-Camal et al, 2022). Amongst one of the most prescribed class of antidepressants are the selective serotonin reuptake inhibitors (SSRIs) (Macaluso and Preskorn, 2019), which block the reuptake of serotonin at the pre-synaptic terminals for enhancing serotonin signaling in the post-synaptic neuron (Gornik et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles

et al. 2022

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The number of people suffering from mental health problems is rising, with anxiety and depression now the most commonly diagnosed psychiatric conditions. Selective serotonin reuptake inhibitors (SSRIs) are one of the most prescribed pharmaceuticals to treat these conditions, which has led to their common detection in many aquatic ecosystems. As the monoaminergic system shows a high degree of structural conservation across diverse animal phyla, a reasonable assumption is that the environmental levels of SSRIs in surface water can lead to adverse effects on fish and other aquatic wildlife. For instance, Sertraline (SER), a widely prescribed SSRI, has been shown to induce adverse effects in fish, albeit most of the reports used exposure concentrations exceeding those occurring in natural environments. Therefore, there is still a great lack of knowledge regarding SERs effects in fish species, especially during early life stages. This study describes the evaluation of developmental exposure of zebrafish (Danio rerio) to environmentally relevant concentrations of SER (from 0.01 to 10 μg/L), using a battery of key survival behaviors and further relating them with the expression of genes and neurochemical profiles of the monoaminergic system. We found that developmental exposure to SER did not affect embryo morphogenesis and growth. However, concentrations as low as 0.1 μg/L induced hypolocomotion and delayed learning. The observed behavioral impairment was associated with augmented serotonin levels rather than other neurochemicals and molecular markers, highlighting the relationship between serotonin signaling and behavior in zebrafish.

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Section: Introductionmentioning

confidence: 99%

Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles

et al. 2022

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“…Recently, the incidence of depression, a type of mental illness, has been on the rise, possibly owing to the 2019 coronavirus disease (COVID-19) pandemic, leading to an increase in the use of antidepressants [ 1 , 2 , 3 ]. Antidepressant compounds have been continuously released into aquatic environments due to their overuse and careless discarding, as well as insufficient removal from wastewater treatment systems [ 4 , 5 ]. Antidepressant concentrations have been detected ranging from ng/L to μg/L in North American and European surface waters and sediments [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Selective serotonin reuptake inhibitors (SSRIs) are currently one of the most widely used antidepressants to treat depression [ 5 , 10 ]. Serotonin is an important neurotransmitter found in a variety of living organisms and participates in many physiological processes, such as metabolism, growth, and reproduction [ 4 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Paroxetine on Benthic Microbial Food Web and Nitrogen Transformation in River Sediments

Chen

Wang

et al. 2022

IJERPH

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Paroxetine is a common pharmaceutical to treat depression and has been found to pose threats to aquatic organisms. However, little is known about the effects of paroxetine on the nutrient cycle in aquatic environments. Therefore, DNA metabarcoding is used in this study to analyze the effects of paroxetine on multi-trophic microorganisms and nitrogen transformation in river sediments. Although paroxetine has no significant effect on the diversity of microbenthos, changes in benthic nitrogen-converting bacteria are consistent with the change in the various forms of nitrogen in the sediment, indicating that paroxetine affects the nitrogen conversion process by affecting nitrogen-converting bacteria. In addition, it is found that paroxetine has the ability to influence nitrogen transformation in an indirect way by affecting the trophic transfer efficiency of higher trophic levels (meiofauna and protozoa, protozoa and protozoa), subsequently affecting the growth of nitrogen-converting bacteria through a top-down mechanism (i.e., predation).The results show that paroxetine affects nitrogen transformation directly by affecting nitrogen-converting bacteria and indirectly through top-down effects, emphasizing that the assessment of paroxetine’s ecological risks should consider species within different trophic levels.

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“…Considering that under certain locations such as wastewater treatment plants these antidepressants, excreted at effective concentrations after human consumption, coexist with pathogenic bacteria, the results obtained by Ding et al (2022) highlight an important blind spot in the warfare against antibiotics resistance. In fact, the sudden peak in depression cases caused by COVID-19 also had a great impact on the consumption of antidepressants, with data showing up to a 15-fold increase the presence in the environment, especially in wastewater treatment plants (Díaz-Camal et al, 2022). These results are alarming considering the effects described by Ding et al (2022) on HGT rates caused by these drugs in bacterial populations.…”

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confidence: 99%

“…With this gradual increase in depressive disorders, also comes a significant rise in prescription of antidepressants. According to the last report from the Organization for Economic Co‐Operation and Development (OECD), the consumption of antidepressants has more than duplicated from 2000 to 2019 (Díaz‐Camal et al, 2022). Recent studies expose the involvement of several antidepressants (either alone or combined with antibiotics) in the development of antibiotic resistance in bacteria (Gurpinar et al, 2022; Shi et al, 2022).…”

mentioning

confidence: 99%

Antidepressants: A new front in the war against antibiotics resistance

Cerna-Vargas

Marcos‐Torres

2022

Environmental Microbiology

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Consumption and ocurrence of antidepressants (SSRIs) in pre- and post-COVID-19 pandemic, their environmental impact and innovative removal methods: A review

Cited by 65 publications

References 106 publications

Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles

Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles

The Effects of Paroxetine on Benthic Microbial Food Web and Nitrogen Transformation in River Sediments

Antidepressants: A new front in the war against antibiotics resistance

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