The abuse of illicit drugs during pregnancy is a very worrying issue that must be addressed in our society. Since, the components present in these substances of abuse can cause various maternal and fetal harm during the gestational period and after birth. The objective of this study is to analyze the main results of the pathophysiological, epidemiological and clinical aspects of the use of these illicit drugs during pregnancy. Through an integrative literature review of a descriptive nature with a qualitative approach in the databases, Lilacs, Scielo, Pubmed, Uptodate in the period from 2018 to 2023. The results of this research are expected to provide a greater understanding of this situation, as despite being a important problem, it lacks studies.