Consuming oral cannabidiol prior to a standard alcohol dose has minimal effect on breath alcohol level and subjective effects of alcohol

Karoly, Hollis C.; Drennan, M L; Prince, Mark A.; Zulic, Leila; Dooley, Gregory P.

doi:10.1007/s00213-023-06349-z

Cited by 1 publication

(1 citation statement)

References 54 publications

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“…Karoly and colleagues administered CBD (30 mg, 200 mg) and a standard dose of alcohol (0.6 g/kg) to examine the effects on the BAES and SEAS. Findings from this study show a significant difference between 200 mg of CBD and alcohol alone on changes in stimulation and sedation (BAES subscales), such that 200 mg of CBD was associated with a slower reduction in stimulation during the descending limb of the blood alcohol concentration (BrAC) curve Karoly et al, 2023. However, the authors concluded that the overall effects of CBD on the subjective effects of alcohol were minimal, given the small magnitude of differences between slopes and the wide Bayesian credible intervals.…”

Section: Cannabidiol and Alcoholmentioning

confidence: 80%

The effects of simultaneous alcohol and cannabis use on subjective drug effects: A narrative review across methodologies

Bedillion,

Claus,

Wemm

et al. 2024

Alcohol, Clinical and Experimental Research

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Over 75% of young adults who use cannabis also report drinking alcohol, leading to increased risks that include impaired cognition, substance use disorders, and more heavy and frequent substance use. Studies suggest that subjective responses to either alcohol or cannabis can serve as a valuable indicator for identifying individuals at risk of prolonged substance use and use disorder. While laboratory studies show additive effects when alcohol and cannabis are used together, the impact of co‐using these substances, specifically with respect to cannabidiol, on an individual's subjective experience remains unclear. This narrative review explores the effects of simultaneous alcohol and cannabis (SAM) use on subjective drug effects, drawing from qualitative research, laboratory experiments, and naturalistic studies. Experimental findings are inconsistent regarding the combined effects of alcohol and cannabis, likely influenced by factors such as dosage, method of administration, and individual substance use histories. Similarly, findings from qualitative and naturalistic studies are mixed regarding subjective drug effects following SAM use. These discrepancies may be due to recall biases, variations in assessment methods, and the measurement in real‐world contexts of patterns of SAM use and related experiences. Overall, this narrative review highlights the need for more comprehensive research to understand more fully subjective drug effects of SAM use in diverse populations and settings, emphasizing the importance of frequent and nuanced assessment of SAM use and subjective responses in naturalistic settings.

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Section: Cannabidiol and Alcoholmentioning

confidence: 80%