Consuming<i>Lentinula edodes</i>(Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults

Dai, Xiaoshuang; Stanilka, Joy M; Rowe, Cheryl A.; Esteves, Elizabethe Adriana; Nieves, Carmelo; Spaiser, Samuel J.; Christman, Mary C.; Langkamp‐Henken, Bobbi; Percival, Susan S.

doi:10.1080/07315724.2014.950391

Cited by 93 publications

(65 citation statements)

References 28 publications

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“…Other Nutraceuticals. Foods that contain nutrients that may help to boost immune function include Shiitake mushrooms (Dai et al 2015;Feeney et al 2014), Reishi mushrooms (Sanodiya et al 2009), aged garlic (Percival 2016), and echinacea (Block and Mead 2003;Karsch-Volk et al 2014). Besides vitamin D (the most important of all nutraceuticals for immune function), other vitamins that strengthen immunity include vitamin C and vitamin E (De la Fuente et al 1998;Moriguchi and Muraga 2000).…”

Section: Pay Attention To Physical Healthmentioning

confidence: 99%

Maintaining Health and Well-Being by Putting Faith into Action During the COVID-19 Pandemic

2020

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Anxiety and fear adversely affect the physiological systems that protect individuals from infection. This article comments on the role that religious faith and practice can play in helping individuals remain free from infection by the coronavirus and in helping to moderate the effects of infection if that should occur. The author provides six recommendations to help individuals maintain spiritual, mental, and physical resilience during these anxious times of the COVID-19 pandemic.

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Section: Pay Attention To Physical Healthmentioning

confidence: 99%

Maintaining Health and Well-Being by Putting Faith into Action During the COVID-19 Pandemic

2020

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“…After 12 weeks of oral supplementation, 80% of patients had enhanced cellular immunity, displaying elevated levels of plasma IFN-γ, IL-2, and IL-6, along with increased NK cell activity. Likewise, another clinical trial showed that supplementing the diet of 52 healthy, young males and females with 5g or 10g of dried shiitake ( Lentinula edodes ) mushrooms for 4 weeks improved the immune response by increasing cell proliferation and activation of γδ-T and NK-T cells [92]. Cytokine secretion patterns also changed significantly after consumption of the mushroom, with increased levels of IL-4, IL-10, and IL-1α and decreased levels of acute inflammatory cytokines such as macrophage inflammatory protein 1α (MIP1α).…”

Section: Clinical Trialsmentioning

confidence: 99%

Modulation of Toll-like receptor signaling in innate immunity by natural products

Chen

2016

International Immunopharmacology

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For centuries, natural products and their derivatives have provided a rich source of compounds for the development of new immunotherapies in the treatment of human disease. Many of these compounds are currently undergoing clinical trials, particularly as anti-oxidative, anti-microbial, and anti-cancer agents. However, the function and mechanism of natural products in how they interact with our immune system has yet to be extensively explored. Natural immune modulators may provide the key to control and ultimately defeat disorders affecting the immune system. They can either up- or down-regulate the immune response with few adverse side effects. In this review, we summarize the recent advancements made in utilizing natural products for immunomodulation and their important molecular targets, members of the Toll-like receptor (TLR) family, in the innate immune system.

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“…The effective compound of shiitake mushrooms is the thermolabile beta-glucan lentinan[167]. The raw shiitake mushrooms cause toxic dermatitis by reaction to lentinan thermolabile polysaccharide[168].…”

Section: Why the Cancer Cells Survive And How To Reject Them?mentioning

confidence: 99%

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Bukovský

2016

WJSC

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Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo. Lack of proper differentiation of tissue cells by TCS causes either tissue underdevelopment, e.g., muscular dystrophy, or degenerative functional failures, e.g., type 1 diabetes and age-associated diseases. With the gradual IMS regression after 35 years of age the gonadal infertility develops, followed by a growing incidence of age-associated diseases and cancers. Without restoring an altered TCS function in a degenerative disease, the implantation of tissue-specific stem cells alone by regenerative medicine can not be successful. Transfused young blood could temporarily restore fertility to enable parenthood. The young blood could also temporarily alleviate aging diseases, and this can be extended by substances inducing IMS regeneration, like the honey bee propolis. The local and/or systemic use of honey bee propolis stopped hair and teeth loss, regressed varicose veins, improved altered hearing, and lowered high blood pressure and sugar levels. Complete regression of stage IV ovarian cancer with liver metastases after a simple elaborated immunotherapy is also reported.

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ConsumingLentinula edodes(Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults

Cited by 93 publications

References 28 publications

Maintaining Health and Well-Being by Putting Faith into Action During the COVID-19 Pandemic

Maintaining Health and Well-Being by Putting Faith into Action During the COVID-19 Pandemic

Modulation of Toll-like receptor signaling in innate immunity by natural products

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

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