Research shows that perceived naturalness can bias beliefs about the positivity of items such as food, human talent, and vaccines. Yet, this research focuses on self-reports, which leaves open the implications it has for behavior. In four studies ( N = 492), we tested if perceived naturalness impacts trivial and meaningful behaviors. Participants were asked to consume a purported natural/synthetic performance drink (Study 1), test a purported natural/synthetic drug that would be injected (Study 2), eat chocolate containing a purported natural/synthetic cocoa described as causing stomach discomfort (Study 3), or choose a sticker purportedly made with natural/synthetic ink (Study 4). A significant majority of participants (66%–84%) chose and followed through with the natural versus synthetic option. Perceived naturalness guided behavior in contexts involving little (sticker choice) to substantial (drug injection) potential consequences. Self-reports can weakly predict behaviors, but the results revealed that perceived naturalness biases self-reports and behaviors in a similar fashion.