Construction of Tip60-Encoding Plasmid and the Effect of Tip60 on the Expression of HPV18 Genes in HeLa Cells

Lai, Yongwei; Liu, Xuena; Wang, Yijie; Yue, Yunpeng; Liu, Xiang; Zhou, Hao; Wang, Nan; Luo, Xue‐Gang; Ma, Wenjian; Zhang, Tongcun; He, Hongbin

doi:10.1007/978-981-10-4801-2_75

Cited by 1 publication

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“…When TIP60 was overexpressed, the expression of HPV18 e6 and e7 genes was significantly inhibited. In addition, the co-overexpression of TIP60 and ep400 in HeLa cells synergistically inhibited the expression of HPV18 e6-e7 [73]. Overexpression of TIP60 reduces the DNA methylation levels in HeLa cells [74].…”

Section: Histone Acetyltransferases (Hats)mentioning

confidence: 99%

The function of histone acetylation in cervical cancer development

et al. 2019

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Cervical cancer is the fourth most common female cancer in the world. It is well known that cervical cancer is closely related to high-risk human papillomavirus (HPV) infection. However, epigenetics has increasingly been recognized for its role in tumorigenesis. Epigenetics refers to changes in gene expression levels based on non-gene sequence changes, primarily through transcription or translation of genes regulation, thus affecting its function and characteristics. Typical post-translational modifications (PTMs) include acetylation, propionylation, butyrylation, malonylation and succinylation, among which the acetylation modification of lysine sites has been studied more clearly so far. The acetylation modification of lysine residues in proteins is involved in many aspects of cellular life activities, including carbon metabolism, transcriptional regulation, amino acid metabolism and so on. In this review, we summarize the latest discoveries on cervical cancer development arising from the aspect of acetylation, especially histone acetylation.

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Section: Histone Acetyltransferases (Hats)mentioning

confidence: 99%