Construction of tea tree oil/salicylic acid/palygorskite hybrids for advanced antibacterial and anti-inflammatory performance

Zhang, Xi; Cao, Lei; Li, Huiyu; Xiong, Zhenzhen; Fu, Zhengpeng; Zhang, Zhaolun; Xie, Wei; Cui, Hongyan; Zhang, Shuang; Tang, Y; Yang, Feng

doi:10.1039/d2tb02797f

Cited by 7 publications

(2 citation statements)

References 55 publications

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“…Mohammed In a general way, the antibacterial activity of the NE is dependent on its composition, and experimental strains. It has been reported that BB, TTO, and glycyrrhizic acid have an excellent bacteriostatic effect on S. aureus [12,16,55]. Yang et al [12] proved that BB can destroy the permeability of the cell membrane, and inhibit the synthesis of bacterial nucleic acid and protein against S. aureus.…”

Section: Antibacterial Evaluationmentioning

confidence: 99%

“…Tea tree oil (TTO) is a colorless-to-light-yellow oily liquid with an aromatic smell, extracted from the fresh leaves of the tea tree; it is rich in a variety of biological active substances, such as terpenes [15]. Because of its broad spectrum of antibacterial [16], anti-inflammatory, and other biological activities [17], it has been widely used in medicine, food, and other industries. However, plant EOs have some disadvantages, such as a poor water solubility and easy decomposition [18], which limit their further application.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and Biological Activities of All-in-One Composite Nanoemulsion Based on Blumea balsamifera Oil-Tea Tree Oil

et al. 2023

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Nanoemulsion is a new multi-component drug delivery system; the selection of different oil phases can give it special physiological activity, and play the role of “medicine and pharmaceutical excipients all-in-one”. In this paper, we used glycyrrhizic acid as the natural surfactant, and Blumea balsamifera oil (BB) and tea tree oil (TTO) as the mixed oil phase, to obtain a new green functional composite nanoemulsion. Using the average particle size and polydispersion index (PDI) as the evaluation criteria, the effects of the oil ratio, oil content, glycyrrhizic acid concentration, and ultrasonic time on the nanoemulsion were systematically investigated. The stability and physicochemical properties and biological activities of BB-TTO NEs prepared via the optimum formulation were characterized. The optimal prescription was BB: TTO = 1:1, 5% oil phase, 0.7% glycyrrhizic acid, and 5 min ultrasonication time. The mean particle size, PDI, and zeta potential were 160.01 nm, 0.125, and −50.94 mV, respectively. The nanoemulsion showed non-significant changes in stability after centrifugation, dilution, and 120 days storage. These nanoemulsions were found to exhibit potential antibacterial and anti-inflammatory activities. The minimal inhibitory concentration (MIC) of BB-TTO NEs against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa is 2975 μg/mL, 2975 μg/mL, and 5950 μg/mL, respectively. A lower level of inflammatory cell infiltration and proportion of fibrosis were found in the synovial tissue of AIA rats treated with BB-TTO NEs. These findings demonstrate that the BB-TTO NEs produced in this study have significant potential for usage in antibacterial and anti-inflammatory areas.

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Section: Antibacterial Evaluationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication and Biological Activities of All-in-One Composite Nanoemulsion Based on Blumea balsamifera Oil-Tea Tree Oil

et al. 2023

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Synthesis and characteristics of biocidal oil composites enhanced with thymol and salicylic acid

Staroń,

Pucelik,

Barzowska

et al. 2024

Clean Techn Environ Policy

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The research aimed to develop composite materials based on waste cooking oil containing thymol or salicylic acid and assess their antimicrobial properties against selected Gram-positive and Gram-negative bacteria strains. The study also investigated whether the use of a binder, such as catalyzed waste cooking oil, and the performing of annealing process would affect the antimicrobial effectiveness of the natural additive. The composite materials were characterized using FT–IR spectroscopy, thermal analysis, and scanning electron microscopy. Mechanical properties were also evaluated, along with abrasion resistance and soakability. Thymol-modified materials showed higher activity against E. coli strain; while, salicylic acid-modified materials were more effective against P. aeruginosa. The antibacterial activity against Gram-positive bacteria was generally lower than against Gram-negative bacteria. Flow cytometry and confocal microscopy were used to visualize and quantify bacterial death induced by the composite materials. The materials showed interactions with bacterial cells, leading to cell damage and inhibition of bacterial division. The most effective biocidal composite against the suspension of P. aeruginosa bacteria was 22 T (99% inactivation), containing 4% thymol. Against E. coli, composite 41 T containing 1% thymol caused a significant decrease in the viability of these bacteria by up to 45%. Similarly, on S. aureus, composites with the addition of thymol also exhibited strong effects, reaching up to 70% reduction, as observed in 43 T with 7% thymol. Composites containing salicylic acid also demonstrated biocidal properties, resulting in a 52% reduction in E. coli (33SA containing 7% salicylic acid); 99% reduction in P. aeruginosa (15SA containing 1% salicylic acid); 20% reduction in S. aureus (41SA containing 1% salicylic acid); and approximately 25% reduction in S. epidermidis (43SA with 7% salicylic acid). Furthermore, the composite materials demonstrated low cytotoxicity against human keratinocytes, indicating their potential safe use when contacted with human skin. Graphical Abstract

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Design of hydrophobic zein/dye-LDHs biohybrid pigments for cosmetic applications

Zhang,

Tang,

Wang

et al. 2024

Applied Clay Science

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Construction of tea tree oil/salicylic acid/palygorskite hybrids for advanced antibacterial and anti-inflammatory performance

Abstract: This study describes the construction of a tailor-made clay-based hybrid with advanced dermocompatibility, antibacterial and anti-inflammatory performances by incorporating tunable ratios of tea tree oil (TTO) and salicylic acid (SA)...

Cited by 7 publications

References 55 publications

Fabrication and Biological Activities of All-in-One Composite Nanoemulsion Based on Blumea balsamifera Oil-Tea Tree Oil

Fabrication and Biological Activities of All-in-One Composite Nanoemulsion Based on Blumea balsamifera Oil-Tea Tree Oil

Synthesis and characteristics of biocidal oil composites enhanced with thymol and salicylic acid

Design of hydrophobic zein/dye-LDHs biohybrid pigments for cosmetic applications

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