Construction of targeted delivery system for curcumin loaded on magnetic α-Fe2O3/Fe3O4 heterogeneous nanotubes and its apoptosis mechanism on MCF-7 cell

Liu, Ruijiang; Zhang, Yanling; Deng, Peng; Huang, Wei; Yin, Ruitong; Yu, Lulu; Li, You; Zhang, Shaoshuai; Ni, Yun; Chen, Ling; Zhu, Ziye; Wu, Shaobo; Li, Shasha

doi:10.1016/j.bioadv.2022.212783

Cited by 10 publications

(5 citation statements)

References 60 publications

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“…Also, according to previous studies, piperine-loaded nanoparticles have effective anti-tumor activity (Table 2, entry 7-8) [50,51]. Among MNPs, curcumin was loaded on Fe 3 O 4 coated with carboxymethyl chitosan [35], and liposome-coated α-Fe 2 O 3 /Fe 3 O 4 heterogeneous nanotubes [37] showed a signi cant reduction compared to free curcumin on MCF-7 cells (Table 2, entry 9-10). To the best of the authors' knowledge, there has been no study on the cytotoxic and synergistic effects of curcumin and piperine, separately or used together, on MNPs.…”

Section: Discussionmentioning

confidence: 73%

“…They investigated the growth rate and viability of cancer cells by MTT assay and concluded that polymer nanoparticles containing piperine prevent the growth of cancer cells by stimulating apoptosis. In 2022, Liu and coworkers [37] loaded curcumin on liposome-coated α-Fe 2 O 3 /Fe 3 O 4 heterogeneous nanotubes for e cient delivery of curcumin to MCF-7 cancer cells so that curcumin encapsulation e ciency in the α-Fe 2 O 3 /Fe 3 O 4 -CUR@LIP nanocomposites reached 82.1 ± 0.9%. The results of MTT assays showed that magnetic eld considerably increased the cytotoxicity of α-Fe 2 O 3 /Fe 3 O 4 -CUR@LIP nanocomposites on MCF-7 cells.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin- and Piperine-Loaded Fe3o4@Sio2 Magnetic Nanoparticles: Synthesis, Characterization, and Comparison of the Effects on Mcf-7 Breast Cancer Cell Line

Rezaeidian

Naseh

Entezari

et al. 2023

Preprint

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Curcumin- and Piperine-Loaded Fe3o4@Sio2 Magnetic Nanoparticles: Synthesis, Characterization, and Comparison of the Effects on Mcf-7 Breast Cancer Cell Line

Rezaeidian

Naseh

Entezari

et al. 2023

Preprint

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“…Magnetic nanomaterials have many unique advantages (Liu et al., 2022 ; Zhang et al., 2022 b) and have been used in many aspects of production and life (Ni et al., 2022 ; Yu et al., 2022b ). Magnetic nanoparticles are primarily composed of Fe, Ni, Co, Cu, and their oxides.…”

Section: Introductionmentioning

confidence: 99%

Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂ -FA nanocomposites to MCF-7 cells

Deng

Yin

et al. 2022

Drug Delivery

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Magnetic Fe 3 O 4 nanoparticles were prepared via a simple hydrothermal method and utilized to load paclitaxel. The average particle size of Fe 3 O 4 nanoparticles was found to be 20.2 ± 3.0 nm, and the calculated saturation magnetization reached 129.38 emu/g, verifying superparamagnetism of nanomaterials. The specific surface area and pore volume were 84.756 m 2 /g and 0.265 cm 3 /g, respectively. Subsequently, Fe 3 O 4 @mSiO 2 nanoparticles were successfully fabricated using the Fe 3 O 4 nanoparticles as precursors with an average size of 27.81 nm. The relevant saturation magnetization, zeta potential, and specific surface area of Fe 3 O 4 @mSiO 2 -NH 2 -FA were respectively 76.3 emu/g, −14.1 mV, and 324.410 m 2 /g. The pore volume and average adsorption pore size were 0.369 cm 3 /g and 4.548 nm, respectively. Compared to free paclitaxel, the solubility and stability of nanoparticles loaded with paclitaxel were improved. The drug loading efficiency and drug load of the nanoformulation were 44.26 and 11.38%, respectively. The Fe 3 O 4 @mSiO 2 -NH 2 -FA nanocomposites were easy to construct with excellent active targeting performance, pH sensitivity, and sustained-release effect. The nanoformulation also showed good biocompatibility, where the cell viability remained at 73.8% when the concentration reached 1200 μg/mL. The nanoformulation induced cell death through apoptosis, as confirmed by AO/EB staining and flow cytometry. Western blotting results suggested that the nanoformulation could induce iron death by inhibiting Glutathione Peroxidase 4 (GPX4) activity or decreasing Ferritin Heavy Chain 1 (FTH1) expression. Subsequently, the expression of HIF-1α was upregulated owing to the accumulation of reactive oxygen species (ROS), thus affecting the expression of apoptosis-related proteins regulated by p53, inducing cell apoptosis.

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“…Fe 3 O 4 nanoparticles and Fe 3 O 4 nanocomposites are widely used in biosensing, catalysis, targeted drug delivery, and environmental remediation research [8][9][10]. Fe 3 O 4 nanomaterials have many advantages such as large specific surface area, low toxicity, superparamagnetism, and easy functionalization [11].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of Fe₃O₄ nanoparticles via a hydrothermal process with propanediol as the solvent

Liu

Zhang

Xu³

2022

Mater. Res. Express

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Fe3O4 nanomaterials have received great attention in various technology fields. However, the limitations are Fe3O4 is easy to agglomerate and obtaining Fe3O4 nanoparticles of tunable magnetism and controllable size, and well-dispersed ability remains a challenge. In this study, a simple hydrothermal process with propanediol as the solvent was used to prepare Fe3O4 nanoparticles. In the optimization of preparation conditions, three key factors (hydrothermal temperature, hydrothermal time, and solvent volume) were optimized by X-ray diffraction (XRD) and vibrating sample magnetometer (VSM). The results showed that the magnetism and the phase content of the prepared Fe3O4 were controllable during the optimization process. The optimum hydrothermal temperature was 170 ℃, hydrothermal time was 18 h and solvent volume was 40 mL. The elemental composition, surface morphology, and magnetic properties of Fe3O4 nanoparticles were characterized. The prepared Fe3O4 nanoparticles exhibited superparamagnetic properties and high crystallinity, with an average particle size of 20 nm, a specific surface area of 84.756 m2/g, a pore volume of 0.265 cm3/g, and saturation magnetization (Ms) of 129.38 emu/g.

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Construction of targeted delivery system for curcumin loaded on magnetic α-Fe2O3/Fe3O4 heterogeneous nanotubes and its apoptosis mechanism on MCF-7 cell

Cited by 10 publications

References 60 publications

Curcumin- and Piperine-Loaded Fe3o4@Sio2 Magnetic Nanoparticles: Synthesis, Characterization, and Comparison of the Effects on Mcf-7 Breast Cancer Cell Line

Curcumin- and Piperine-Loaded Fe3o4@Sio2 Magnetic Nanoparticles: Synthesis, Characterization, and Comparison of the Effects on Mcf-7 Breast Cancer Cell Line

Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂ -FA nanocomposites to MCF-7 cells

Preparation and characterization of Fe₃O₄ nanoparticles via a hydrothermal process with propanediol as the solvent

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Construction of targeted delivery system for curcumin loaded on magnetic α-Fe2O3/Fe3O4 heterogeneous nanotubes and its apoptosis mechanism on MCF-7 cell

Cited by 10 publications

References 60 publications

Curcumin- and Piperine-Loaded Fe3o4@Sio2 Magnetic Nanoparticles: Synthesis, Characterization, and Comparison of the Effects on Mcf-7 Breast Cancer Cell Line

Curcumin- and Piperine-Loaded Fe3o4@Sio2 Magnetic Nanoparticles: Synthesis, Characterization, and Comparison of the Effects on Mcf-7 Breast Cancer Cell Line

Effect and mechanism of paclitaxel loaded on magnetic Fe 3 O 4 @mSiO 2 -NH 2 -FA nanocomposites to MCF-7 cells

Preparation and characterization of Fe3O4 nanoparticles via a hydrothermal process with propanediol as the solvent

Contact Info

Product

Resources

About

Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂ -FA nanocomposites to MCF-7 cells

Preparation and characterization of Fe₃O₄ nanoparticles via a hydrothermal process with propanediol as the solvent