Construction of stomach adenocarcinoma prognostic signature based on anoikis-related lncRNAs and clinical significance

Abstract

As a dominant type of gastric cancer, stomach adenocarcinoma (STAD) is characterized by high morbidity and mortality rates. Anoikis factors participate in tumor metastasis and invasion. This study was designed to identify prognostic risk factors in anoikis-related long non-coding RNAs (lncRNAs) for STAD. First, with STAD expression datasets and anoikis-related gene sets downloaded from public databases, anoikis-related prognostic lncRNA signatures (AC091057.1, ADAMTS9.AS1, AC090825.1, AC084880.3, EMX2OS, HHIP.AS1, AC016583.2, EDIL3.DT, DIRC1, LINC01614, and AC103702.2) were screened by Cox regression to establish a prognostic risk model. Kaplan–Meier and receiver operating characteristic curves were used to evaluate the survival status of patients and verify predictive accuracy of the model. Besides, risk score could be an independent prognostic factor to assess the prognosis of STAD patients. Nomograms of the prognostic model that combined clinical information and risk score could effectively predict survival of STAD patients, as validated by calibration curve. Gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses were performed for differentially expressed genes (DEGs) in high- and low-risk groups. These DEGs were related to neurotransmitter transmission, signal transmission, and endocytosis. Moreover, we analyzed immune status of different risk groups and found that STAD patients in low-risk group were more sensitive to immunotherapy. A prognostic risk assessment model for STAD using anoikis-related lncRNA genes was constructed here, which was proven to have high predictive accuracy and thus could offer a reference for prognostic evaluation and clinical treatment of STAD patients.

Prognostic Implication of Plasma Metabolites in Gastric Cancer

“…Owing to their intuitive visual presentation and personalized application, nomograms have become a popular tool for oncology prognosis [ 7 , 21 ]. Lu et al [ 22 ] constructed a stomach adenocarcinoma prognostic signature based on anoikis-related lncRNAs and clinical significance. The values of AUC at 1, 3, and 5 years were 0.62, 0.69, and 0.68, respectively.…”

Exploring the association between inflammatory biomarkers and gastric cancer development: A two-sample mendelian randomization analysis.

“…Stomach cancer, known for its alarming prevalence and mortality, stands as the fifth most diagnosed malignancy globally and occupies the third position in cancer-related mortality as per the World Health Organization. [ 1 , 2 ] The geographic disparity in incidence rates is pronounced, with East Asian nations like China, Japan, and South Korea experiencing heightened rates, [ 3 , 4 ] in stark contrast to the lower incidences observed in North America and select European regions. The male population bears a disproportionately higher burden of this disease, [ 5 – 7 ] which may stem from gender-specific variations in diet, lifestyle, and genetic factors.…”