Construction of polymer coated core–shell magnetic mesoporous silica nanoparticles with triple responsive drug delivery

Hegazy, Mohammad; Zhou, Pei; Wu, Guangyu; Wang, Lei; Rahoui, Nahla; Taloub, Nadia; Huang, Xin; Huang, Yudong

doi:10.1039/c7py01179b

Cited by 74 publications

(35 citation statements)

References 69 publications

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“…However, this difference was not remarkable in the case of pH 5.5 [96]. Hegazy et al [97] reported a triple stimuli-responsive drug delivery system based on mesoporous silica and iron oxide nanoparticles. They used iron oxide (Fe 3 O 4 ) nanoparticles as a core with mesoporous silica coating loaded with ICG and DOX and functionalized with thermoresponsive PNIPAAM through disulfide linker.…”

Section: Dual/multi-responsive Ddsmentioning

confidence: 99%

“…They used iron oxide (Fe 3 O 4 ) nanoparticles as a core with mesoporous silica coating loaded with ICG and DOX and functionalized with thermoresponsive PNIPAAM through disulfide linker. Nanoparticles showed higher drug release at a higher temperature and in the presence of a reducing agent, tris(2-carboxyethyl) phosphine (TCEP) [97].…”

Section: Dual/multi-responsive Ddsmentioning

confidence: 99%

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Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

et al. 2019

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In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. This particular work focuses on the smart chemistry and mechanism of action aspects of several types of stimuli-responsive polymeric carriers that play a crucial role in extracellular and intracellular sections of diseased tissues or cells. With ever increasing scientific knowledge and awareness, research is underway around the globe to design new types of stimuli (external/internal) responsive polymeric carriers for biotechnological applications at large and biomedical and/or pharmaceutical applications, in particular. Both external/internal and even dual/multi-responsive behavior of polymeric carriers is considered an essential element of engineering so-called ‘smart’ DDS, which controls the effective and efficient dose loading, sustained release, individual variability, and targeted permeability in a sophisticated manner. So far, an array of DDS has been proposed, developed, and implemented. For instance, redox, pH, temperature, photo/light, magnetic, ultrasound, and electrical responsive DDS and/or all in all dual/dual/multi-responsive DDS (combination or two or more from any of the above). Despite the massive advancement in DDS arena, there are still many challenging concerns that remain to be addressed to cover the research gap. In this context, herein, an effort has been made to highlight those concerning issues to cover up the literature gap. Thus, the emphasis was given to the drug release mechanism and applications of endogenous and exogenous based stimuli-responsive DDS in the clinical settings.

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Section: Dual/multi-responsive Ddsmentioning

confidence: 99%

Section: Dual/multi-responsive Ddsmentioning

confidence: 99%

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

et al. 2019

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“…Multi-responsive nanocarriers that are sensitive to temperature and redox potential can effectively release their drug payload in the tumor microenvironment. Hegazy et al reported magnetic mesoporous silica nanoparticles (MMSNPs) that have iron oxide nanoparticles as a core inside a mesoporous silica coating [ 99 ]. They can be used in a wide range of disciplines and provide promising results.…”

Section: Multi-responsive Systemsmentioning

confidence: 99%

“…Other results indicated that both a magnetic field and a high temperature enhanced DOX release over time and reached 86% after 24 h, applying reducing potential and temperature together resulted in an 80% release. In summary, simultaneously applying thermal, redox potential, and magnetic-sensitive environments significantly improved the drug release from PNIPAAm/DOx NPs that reached 98% within 24 h [ 99 ]. The amount of drug release triggered by a random combination of two or three stimuli was higher than that mediated by any of the stimuli separately.…”

Section: Multi-responsive Systemsmentioning

confidence: 99%

Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery

2020

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The new era of nanotechnology has produced advanced nanomaterials applicable to various fields of medicine, including diagnostic bio-imaging, chemotherapy, targeted drug delivery, and biosensors. Various materials are formed into nanoparticles, such as gold nanomaterials, carbon quantum dots, and liposomes. The nanomaterials have been functionalized and widely used because they are biocompatible and easy to design and prepare. This review mainly focuses on nanomaterials responsive to the external stimuli used in drug-delivery systems. To overcome the drawbacks of conventional therapeutics to a tumor, the dual- and multi-responsive behaviors of nanoparticles have been harnessed to improve efficiency from a drug delivery point of view. Issues and future research related to these nanomaterial-based stimuli sensitivities and the scope of stimuli-responsive systems for nanomedicine applications are discussed.

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“…Currently, the construction of single (functional) layer of shell is well established [6][7][8][9][10]. On the other hand, multiple layers of shells have to be elaborated for multiple extraneous functions [22][23][24][25]. The introduction of multiple shells, however, makes the preparation complicated and time consuming.…”

Section: Introductionmentioning

confidence: 99%

Correction to: Magnetic-core@dual-functional-shell nanocomposites with peroxidase mimicking properties for use in colorimetric and electrochemical sensing of hydrogen peroxide

Liu

et al. 2019

Microchim Acta

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A self-sacrificing catalytic method is described for the preparation of magnetic core/dual-functional-shell nanocomposites composed of magnetite, gold and Prussian blue (type Fe 3 O 4 @Au-PB). Two reaction pathways are integrated. The first involves chemical dissolution of Fe 3 O 4 (the self-sacrificing step) by acid to release ferrous ions which then reacts with hexacyanoferrate(IV) to generate PB in the proximity of the magntic nanoparticles (MNPs). The second involves the reduction of tetrachloroaurate by hydroxylamine to generate gold under the catalytic effect of the MNPs. At the end, the MNP@Au-PB nanocomposite is formed. This method exploits both the chemical reactivity and catalytic effect of the MNPs in a single step. The multi-function material was applied (a) in an optical assay for H 2 O 2 ; (b) in an amperometric assay for H 2 O 2 ; (c) in an enzymatic choline assay using immobilized choline oxidase. The limit of electrochemical detection of H 2 O 2 (at a potential as low as 50 mV) is 1.

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Construction of polymer coated core–shell magnetic mesoporous silica nanoparticles with triple responsive drug delivery

Abstract: Multi-responsive drug delivery systems are playing a very important role in nanomedicine, as they can feature as smart carriers releasing their payload on demand.

Cited by 74 publications

References 69 publications

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery

Correction to: Magnetic-core@dual-functional-shell nanocomposites with peroxidase mimicking properties for use in colorimetric and electrochemical sensing of hydrogen peroxide

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