Construction of poly-(γ-benzyl‐l‐glutamate) composite microcarriers with osteogenic and angiogenic properties for the restoration of alveolar bone defects

Bu, Shuai; Yu, Meilin; Chen, Qin; Chen, Dong; Xia, Pengfei; Li, Guifei; Zhang, Kunxi; Yan, Shifeng; Wu, Haimiao; Yin, Jingbo

doi:10.1016/j.compositesb.2022.110085

Cited by 6 publications

(3 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In comparison to the other groups, CuS@MSN-SCS exhibited a significantly higher level of CD31-positive angiogenesis (Figure C). This can be attributed to the presence of Cu 2+ ions and SCS derived from CuS@MSN-SCS. , These findings suggest that CuS@MSN-SCS possesses the capacity to alleviate inflammation and accelerate neovascularization for alveolar bone regeneration, thus exhibiting a noteworthy therapeutic effect on periodontitis in vivo .…”

Section: Resultsmentioning

confidence: 85%

Sulfated Chitosan-Modified CuS Nanocluster: A Versatile Nanoformulation for Simultaneous Antibacterial and Bone Regenerative Therapy in Periodontitis

Chen,

Huang,

Wang

et al. 2024

ACS Nano

View full text Add to dashboard Cite

Periodontitis, a prevalent chronic inflammatory disease worldwide, is triggered by periodontopathogenic bacteria, resulting in the progressive destruction of periodontal tissue, particularly the alveolar bone. To effectively address periodontitis, this study proposed a nanoformulation known as CuS@MSN-SCS. This formulation involves coating citrate-grafted copper sulfide (CuS) nanoparticles with mesoporous silica (MSNs), followed by surface modification using amino groups and sulfated chitosan (SCS) through electrostatic interactions. The objective of this formulation is to achieve efficient bacteria removal by inducing ROS signaling pathways mediated by Cu 2+ ions. Additionally, it aims to promote alveolar bone regeneration through Cu 2+ -induced pro-angiogenesis and SCS-mediated bone regeneration. As anticipated, by regulating the surface charges, the negatively charged CuS nanoparticles capped with sodium citrate were successfully coated with MSNs, and the subsequent introduction of amine groups using (3-aminopropyl)triethoxysilane was followed by the incorporation of SCS through electrostatic interactions, resulting in the formation of CuS@MSN-SCS. The developed nanoformulation was verified to not only significantly exacerbate the oxidative stress of Fusobacterium nucleatum, thereby suppressing bacteria growth and biofilm formation in vitro, but also effectively alleviate the inflammatory response and promote alveolar bone regeneration without evident biotoxicity in an in vivo rat periodontitis model. These findings contribute to the therapeutic effect on periodontitis. Overall, this study successfully developed a nanoformulation for combating bacteria and facilitating alveolar bone regeneration, demonstrating the promising potential for clinical treatment of periodontitis.

show abstract

Section: Resultsmentioning

confidence: 85%

Sulfated Chitosan-Modified CuS Nanocluster: A Versatile Nanoformulation for Simultaneous Antibacterial and Bone Regenerative Therapy in Periodontitis

Chen,

Huang,

Wang

et al. 2024

ACS Nano

View full text Add to dashboard Cite

show abstract

“…PLGA-CAS was prepared using the double emulsion method [31,32]. First, 100 mg of PLGA was dissolved in 3 mL of DCM as the oil phase (O).…”

Section: Preparation Of μHa/plga-cas and Nha/plga-casmentioning

confidence: 99%

Enhancing the biological functionality of poly (lactic‐co‐glycolic acid) cage‐like structures through surface modification with micro‐ and nano‐sized hydroxyapatite particles

Chang,

Li,

Bai

et al. 2024

Biosurface and Biotribology

View full text Add to dashboard Cite

Biomaterials with exceptional performance are crucial for addressing the challenges of complex bone regeneration. Compared with traditional three‐dimensional scaffolds, injectable microspheres enable new strategies for the treatment of irregular bone defects. Biodegradable poly (lactic‐co‐glycolic acid) has found widespread applications as microcarriers of drugs, proteins, and other active macromolecules. Applied to the surface of poly (lactic‐co‐glycolic acid) cage‐like structures (PLGA‐CAS), hydroxyapatite (HA) effectively reduces inflammation while enhancing biological effects. In this study, we loaded the surface of PLGA‐CAS with micro‐ and nano‐hydroxyapatite particles, referred to as μHA/PLGA‐CAS and nHA/PLGA‐CAS, respectively. Subsequently, their material characteristics and biological effects were assessed. The incorporation of hydroxyapatite onto PLGA‐CAS resulted in enhanced surface roughness and hydrophilicity, coupled with improved thermal stability and delayed degradation. Furthermore, μHA/PLGA‐CAS induced osteogenic differentiation of osteoblast precursor cells, while nHA/PLGA‐CAS improved endothelial cell adhesion and stimulated angiogenic differentiation in vitro. Collectively, these findings suggest that μHA/PLGA‐CAS and nHA/PLGA‐CAS, each with distinct characteristics, hold significant potential for application as microcarriers in various biomedical contexts.

show abstract

“…Consequently, the last few decades have witnessed the introduction of myriad vascularization strategies within the realms of tissue engineering and regenerative medicine [ 2 , 3 ]. While prior investigations predominantly focused on approaches such as the addition of growth factors, prefabricated vascular networks, and vascular transplantation, these methodologies have grappled with issues of low efficiency and security during practical implementation [ 4 ]. Addressing these challenges necessitates an exploration of the autologous tissue vascularization strategy, which mitigates the risk of disease transmission and obviates the need for post-implantation immunosuppression.…”

Section: Introductionmentioning

confidence: 99%

Combining "waste utilization" and "tissue to tissue" strategies to accelerate vascularization for bone repair

Li,

Wang,

et al. 2024

Journal of Orthopaedic Translation

View full text Add to dashboard Cite

Construction of poly-(γ-benzyl‐l‐glutamate) composite microcarriers with osteogenic and angiogenic properties for the restoration of alveolar bone defects

Cited by 6 publications

References 61 publications

Sulfated Chitosan-Modified CuS Nanocluster: A Versatile Nanoformulation for Simultaneous Antibacterial and Bone Regenerative Therapy in Periodontitis

Sulfated Chitosan-Modified CuS Nanocluster: A Versatile Nanoformulation for Simultaneous Antibacterial and Bone Regenerative Therapy in Periodontitis

Enhancing the biological functionality of poly (lactic‐co‐glycolic acid) cage‐like structures through surface modification with micro‐ and nano‐sized hydroxyapatite particles

Combining "waste utilization" and "tissue to tissue" strategies to accelerate vascularization for bone repair

Contact Info

Product

Resources

About