Construction of poly(lactic-co-glycolic acid)/ZnO nanorods/Ag nanoparticles hybrid coating on Ti implants for enhanced antibacterial activity and biocompatibility

Xiang, Yiming; Li, Jun; Liu, Xiangmei; Cui, Zhenduo; Yang, Xu; Yeung, Kelvin Wai Kwok; Pan, Haobo; Wu, S. L.

doi:10.1016/j.msec.2017.05.115

Cited by 84 publications

(56 citation statements)

References 40 publications

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“…NPs have attracted great interest due to their special or specific properties and selectivity, especially in pharmaceutical and biological applications [8]. In laboratory tests with NPs, different microorganisms have been eliminated within minutes of contact with the NPs [9][10][11][12]. The application of NPs on bacteria is very important since NPs have a tendency to be in the lowest level and directly enter the food chain of the ecosystem [13,14].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Ag-Doped TiO₂ and Ag-Doped ZnO Nanoparticles

Nigussie

Tesfamariam

Tegegne

et al. 2018

International Journal of Photoenergy

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We report in this paper antibacterial activity of Ag-doped TiO2 and Ag-doped ZnO nanoparticles (NPs) under visible light irradiation synthesized by using a sol-gel method. Structural, morphological, and basic optical properties of these samples were investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectrum, and UV-Vis reflectance. Room temperature X-ray diffraction analysis revealed that Ag-doped TiO2 has both rutile and anatase phases, but TiO2 NPs only have the anatase phase. In both ZnO and Ag-doped ZnO NPs, the hexagonal wurtzite structure was observed. The morphologies of TiO2 and ZnO were influenced by doping with Ag, as shown from the SEM images. EDX confirms that the samples are composed of Zn, Ti, Ag, and O elements. UV-Vis reflectance results show decreased band gap energy of Ag-doped TiO2 and Ag-doped ZnO NPs in comparison to that of TiO2 and ZnO. Pathogenic bacteria, such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, were used to assess the antibacterial activity of the synthesized materials. The reduction in the viability of all the three bacteria to zero using Ag-doped ZnO occurred at 60 μg/mL of culture, while Ag-doped TiO2 showed zero viability at 80 μg/mL. Doping of Ag on ZnO and TiO2 plays a vital role in the increased antibacterial activity performance.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Ag-Doped TiO₂ and Ag-Doped ZnO Nanoparticles

Nigussie

Tesfamariam

Tegegne

et al. 2018

International Journal of Photoenergy

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“…Unfortunately, high concentration of nanostructure and prolonging incubation impacted the cellular proliferation and morphology [61]. A strategy to enhance antimicrobial properties of the implants was also used by Xiang et al They used poly(lactic-co-glycolic acid)/ZnO nanorods/Ag nanoparticles hybrid coating on Ti implants (PLGA-ZnO-AgNPs) [62]. Their coating had antimicrobial activity against both Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli).…”

Section: Biocompatibilitymentioning

confidence: 99%

“…Their coating had antimicrobial activity against both Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli). A biocompatibility assessment showed that PLGA-ZnO-AgNPs were less cytotoxic than ZnO or ZnO-Ti against MC3T3-E1 cells [62]. They also used ALP as a marker of osteogenesis and an increased level of that enzyme in cells on the PLGA-ZnO-AgNPs surface was noted [62].…”

Section: Biocompatibilitymentioning

confidence: 99%

Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications

Steckiewicz

Inkielewicz‐Stępniak

2020

Nanomaterials

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Materials sized 1–100 nm are the nanotechnology’s field of interest. Because of the unique properties such as the ability to penetrate biological barriers and a high surface to volume ratio, nanoparticles (NPs) are a powerful tool to be used in medicine and industry. This review discusses the role of nanotechnology in bone-related issues: osteosarcoma (bone cancer), the biocompatibility of the implants and implant-related infections. In cancer therapy, NPs can be used as (I) cytotoxic agents, (II) drug delivery platforms and (III) in thermotherapy. In implant-related issues, NPs can be used as (I) antimicrobial agents and (II) adjuvants to increase the biocompatibility of implant surface. Properties of NPs depend on (I) the type of NPs, (II) their size, (III) shape, (IV) concentration, (V) incubation time, (VI) functionalization and (VII) capping agent type.

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“…The theory of encapsulating Panax ginseng inside a degradable polymer is majorly to sustain drug delivery. Poly(lactic-co-glycolic acid) (PLGA) is a tunable biodegradable polymer which has been approved by Food and Drug Administration (FDA) for its excellence biocompatibility and used in implant coating (Makadia & Siegel, 2011;Xiang et al, 2017). It is composed of co-polymerization of poly(lactic acid) (PLA) and poly(glycolic acid) (PGA) which participate in tuning the degradation properties of this polymer by varying its monomers ratio (Gentile, Chiono, Carmagnola, & Hatton, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effects of different polyaniline emeraldine compositions in electrodepositing ginsenoside encapsulated poly(lactic‐co‐glycolic acid) microcapsules coating: Physicochemical characterization and in vitro evaluation

Lukman

Saidin

2020

J Biomedical Materials Res

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Even though drug‐eluting stent (DES) has prominently reduced restenosis, however, its complication of delayed endothelialization has caused chronic side effect. A coating of ginseng‐based biodegradable polymer could address this issue due to its specific therapeutic values. However, deposition of this type of stable coating on metallic implant often scarce. Therefore, in this study, different polyaniline (PANI) emeraldine compositions were adopted to electrodeposit ginsenoside encapsulated poly(lactic‐co‐glycolic acid) microcapsules coating. The coating surfaces were analyzed using attenuated total reflectance‐Fourier transform infrared spectroscopy, X‐ray photoelectron spectroscopy, scanning electron microscopy, contact angle, and atomic force microscopy instruments. A month coating stability was then investigated with an evaluation of in vitro human umbilical vein endothelial cell analyses consisted of cytotoxicity and cells attachment assessments. The 1.5 mg PANI emeraldine has assisted the formation of stable, uniform, and rounded microcapsules coating with appropriate wettability and roughness. Less than 1.5 mg PANI emeraldine was not enough to drive the formation of microcapsules coating while greater than 1.5 mg caused the deposition of melted microcapsules. The similar coating also has promoted greater cells proliferation and attachment compared to other coating variation. Therefore, the utilization of electrodeposition to deposit a drug‐based polymer coating could be implemented to develop DES, in accordance to stent implantation which ultimately aims for enrich endothelialization.

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Construction of poly(lactic-co-glycolic acid)/ZnO nanorods/Ag nanoparticles hybrid coating on Ti implants for enhanced antibacterial activity and biocompatibility

Cited by 84 publications

References 40 publications

Antibacterial Activity of Ag-Doped TiO₂ and Ag-Doped ZnO Nanoparticles

Antibacterial Activity of Ag-Doped TiO₂ and Ag-Doped ZnO Nanoparticles

Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications

Effects of different polyaniline emeraldine compositions in electrodepositing ginsenoside encapsulated poly(lactic‐co‐glycolic acid) microcapsules coating: Physicochemical characterization and in vitro evaluation

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Construction of poly(lactic-co-glycolic acid)/ZnO nanorods/Ag nanoparticles hybrid coating on Ti implants for enhanced antibacterial activity and biocompatibility

Cited by 84 publications

References 40 publications

Antibacterial Activity of Ag-Doped TiO2 and Ag-Doped ZnO Nanoparticles

Antibacterial Activity of Ag-Doped TiO2 and Ag-Doped ZnO Nanoparticles

Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications

Effects of different polyaniline emeraldine compositions in electrodepositing ginsenoside encapsulated poly(lactic‐co‐glycolic acid) microcapsules coating: Physicochemical characterization and in vitro evaluation

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Antibacterial Activity of Ag-Doped TiO₂ and Ag-Doped ZnO Nanoparticles

Antibacterial Activity of Ag-Doped TiO₂ and Ag-Doped ZnO Nanoparticles