Construction of Phlorotannin-Based Nanoparticles for Alleviating Acute Liver Injury
Fengxian Luo,
Beiwei Zhu,
Di Wu
et al.
Abstract:Acute liver injury (ALI) is a severe health condition with limited treatment options. Phlorotannin (PT), a natural compound extracted from seaweeds, has shown potential in improving liver function. However, its poor stability and bioavailability have limited its applications in vivo. In this study, we developed PT-based nanoparticles (NPs) through a Mannich reaction with glycine, which exhibited good biocompatibility and prolonged circulation time in vivo. Our results revealed that the PT NPs possess strong fr… Show more
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