Construction of novel lncRNA-miRNA-mRNA ceRNA networks associated with prognosis of hepatitis C virus related hepatocellular carcinoma

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

“…Moreover, MALAT1 is related with shorter overall survival of HCC patients [ 99 ]. More specifically, MALAT1 functions by binding and sequestering various miRNAs, thereby influencing cellular functions [ 100 , 101 ]. For example, MALAT1 diminishes the expression of miR-204, leading to the upregulation of silent information regulator 1 (SIRT1) levels and the promotion of epithelial–mesenchymal transition (EMT) [ 102 ].…”

Whole-transcriptome sequencing revealed the role of noncoding RNAs in susceptibility and resistance of Pekin ducks to DHAV-3

“…In addition, a competing endogenous RNA ( ceRNA ) consisting of lncRNAs, miRNAs, and mRNAs have been found in various pathological and physiological conditions, and especially in the virus infection. For examples, the BUB1-hsa-miR-193a-3p-MALAT1 regulatory subnetwork was found in HCV infection ( Shao et al, 2022 ), a ceRNA network containing TRHDE-AS1 and PKIA was found in HBV infection, which related to TPX2 regulation in the HBV-related HCC ( Li et al, 2022 ). However, there is currently no investigation about the roles of ceRNAs in susceptibility and resistance of Pekin ducks to be infected by DHAV-3.…”