Construction of novel amphiphilic chitosan copolymer nanoparticles for chlorpyrifos delivery

Zhang, Jiakun; Li, Min; Fan, Tengfei; Xu, Qing; Wu, Yan; Chen, Chunying; Huang, Qiliang

doi:10.1007/s10965-013-0107-7

Cited by 54 publications

(38 citation statements)

References 35 publications

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“…Recently, we have developed several pesticide nanoparticles that use amphiphilic chitosan (CS)-poly(lactide) and CS-poly(lactide)-1,2-dipalmitoylsn-glycero-3-phosphoethanolamine copolymers as carriers to improve stability and sustained release performance [12,13,14]. However, the loading content (LC) of pesticides was not satisfactory when only organic polymers were employed (less than 20%).…”

Section: Introductionmentioning

confidence: 99%

Quaternized Chitosan-Capped Mesoporous Silica Nanoparticles as Nanocarriers for Controlled Pesticide Release

et al. 2016

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Nanotechnology-based pesticide formulations would ensure effective utilization of agricultural inputs. In the present work, mesoporous silica nanoparticles (MSNs) with particle diameters of ~110 nm and pore sizes of ~3.7 nm were synthesized via a liquid crystal templating mechanism. A water-soluble chitosan (CS) derivative (N-(2-hydroxyl)propyl-3-trimethyl ammonium CS chloride, HTCC) was successfully capped on the surface of pyraclostrobin-loaded MSNs. The physicochemical and structural analyses showed that the electrostatic interactions and hydrogen bonding were the major forces responsible for the formation of HTCC-capped MSNs. HTCC coating greatly improved the loading efficiency (LC) (to 40.3%) compared to using bare MSNs as a single encapsulant (26.7%). The microstructure of the nanoparticles was revealed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The pyraclostrobin-loaded nanoparticles showed an initial burst and subsequent sustained release behavior. HTCC-capped MSNs released faster than bare MSNs in the initial stage. Pyraclostrobin-loaded HTCC-capped MSNs with half doses of pyraclostrobin technical demonstrated almost the same fungicidal activity against Phomopsis asparagi (Sacc.), which obviously reduced the applied pesticide and enhanced the utilization efficiency. Therefore, HTCC-decorated MSNs demonstrated great potential as nanocarriers in agrochemical applications.

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Section: Introductionmentioning

confidence: 99%

Quaternized Chitosan-Capped Mesoporous Silica Nanoparticles as Nanocarriers for Controlled Pesticide Release

et al. 2016

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“…The encapsulation efficiency (EE) and loading capacity of DAGC were calculated by using the following equations:

EE = \frac{Amount of rotenone in DAGC}{Total amount of rotenone} \times 100 %

LC = \frac{italicWeight of rotenone in DAGC}{Weight of DAGC} \times 100 %

…”

Section: Methodsmentioning

confidence: 99%

“…Rotenone release experiment was carried out through an in vitro system using a donor–acceptor compartment system under sink conditions . About 5 mg of rotenone‐loaded DAGC dissolved in 3 mL of phosphate‐buffered saline (PBS) solution (0.1 M , pH 7.4) or free rotenone solution was placed in a dialysis bag with an MWCO of 14,000 Da (donor compartment) and immersed in a 250 mL PBS solution (acceptor compartment) under agitation of 100 rpm at room temperature (25 °C).…”

Section: Methodsmentioning

confidence: 99%

N‐deoxycholic acid‐O‐glycol chitosan as a potential carrier agent for botanical pesticide rotenone

Yusoff

Kamari

2018

J of Applied Polymer Sci

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The potential of amphiphilic chitosan derivative, namely, N-deoxycholic acid-O-glycol chitosan (DAGC), as a carrier agent for pesticide rotenone was assessed for the first time. The physicochemical properties of DAGC were characterized using several analytical instruments such as 1 H-NMR spectrometer, CHN-O elemental analyzer, FTIR spectrometer, TGA, DSC, and UV-visible spectrophotometer. DAGC formed self-aggregation in the solution with a spherical shape of 67.5-83.3 nm. Rotenone-loaded DAGC could give an encapsulation efficiency of up to 91.69%. DAGC micelles exhibit good control release properties as it can prolong the release of rotenone up to 41 h more than free rotenone. The Korsmeyer-Peppas constant (n) values suggest that rotenone release from DAGC micelles was governed by diffusion and relaxation of DAGC chains. The results from this study conclude that DAGC is viable to be applied as a carrier agent in pesticide formulation.

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“…Nanocarrier materials, such as biodegradable polymers, also protect the active ingredient from premature degradation and allow them to be released in a controlled way [14]. Polylactic acid (PLA) and Poly(lactic-co-glycolic) acid (PLGA) are two polymers that have been used as nanocarriers for delivery systems [15], since their biodegradation by-products are non-toxic [16]. Previous studies suggest that the biodegradation in soil of these polymers could take up to several months [17], leaving the molecular diffusion as the dominant mechanism of fungicide liberation to the medium.…”

Section: Introductionmentioning

confidence: 99%

Propiconazole nanoencapsulation in biodegradable polymers to obtain pesticide controlled delivery systems.

et al. 2019

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The nanoencapsulation of pesticides in biodegradable polymers confers several advantages to conventional agrochemicals, such as protection against losses due volatilization and degradation of the active ingredient, as well as the augment of water dispersion, allowing for their application on crops without requiring the use of organic solvents that could harm the user and the environment. This characteristics could enhance the productivity, reducing both costs and environmental pollution. In this work the propiconazole fungicide, forming part of a commercial formulation as well as in its pure state, was encapsulated using as carriers the biodegradable polymer poly lactic acid (PLA) and the biodegradable co-polymer poly (lactic-co-glicolic) acid, all with the aim of generate controlled fungicide release systems to augment the efficiency of the treatments of the Fusarium dieback disease. The most efficient system obtained presented nanospheres of 146.28 nm and an encapsulation efficiency over 42%. The antifungal activity tests showed that the use of this nanoencapsulated fungicide system enhances the growth inhibition percentage in 5%, obtaining a formulation that presents good dispersion in water without the need of organic emulsifier agents.

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Construction of novel amphiphilic chitosan copolymer nanoparticles for chlorpyrifos delivery

Cited by 54 publications

References 35 publications

Quaternized Chitosan-Capped Mesoporous Silica Nanoparticles as Nanocarriers for Controlled Pesticide Release

Quaternized Chitosan-Capped Mesoporous Silica Nanoparticles as Nanocarriers for Controlled Pesticide Release

N‐deoxycholic acid‐O‐glycol chitosan as a potential carrier agent for botanical pesticide rotenone

Propiconazole nanoencapsulation in biodegradable polymers to obtain pesticide controlled delivery systems.

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