Construction of Nanozyme‐Hydrogel for Enhanced Capture and Elimination of Bacteria

Abstract

The widespread multidrug resistance resulting from the abuse of antibiotics motivates researchers to explore alternative methods to treat bacterial infections. Recently, the emergence of nanozymes has provided a potential approach to combat bacteria. Such nanozymes can mimic the functions of natural enzymes to induce the production of highly toxic reactive oxygen species (ROS) as an antibacterial. However, the lack of effective interaction between nanozymes and bacteria, and the intrinsic short lifetime and diffusion distance of ROS greatly compromise their bactericidal activity. Furthermore, the dead bacteria left in the infected area can give rise to unexpected tissue inflammation. Herein, for the first time, a nanozyme-hydrogel is constructed to realize reinforced antibacterials. The nanozyme-hydrogel with the traits of positive charge and macropore can capture and restrict bacteria in the range of ROS destruction. Significantly, by combining the near-infrared photothermal property of nanozymes, the nanozyme-hydrogel can achieve a synergistic bactericidal effect. More importantly, the nanozyme-hydrogel can eliminate bacteria and reduce the risk of inflammation. In consequence, the current work manifests an original strategy to improve the antibacterial performance of nanozymes, concurrently promote wound healing.

When Nanozymes Meet Single‐Atom Catalysis

“…To the best of our knowledge,t he complex protein scaffold is responsible for the high selectivity and efficiency of natural enzymes.However,nanozymes are intrinsically deficient in their fine structure and thus lack the finesse of enzyme-catalyzed reactions,t hereby resulting in unsatisfactory selectivity and activity.I na ddition, the atomic composition and structural complexity of nanomaterials endow ad iverse range of nanozyme catalytic mechanisms.F or example,m any transitionmetal-based nanozymes,such as Fe 3 O 4 , MnO 2 ,V 2 O 5 ,M oS 2 ,a nd so on, with intrinsic peroxidase,o xidase,c atalase,a nd superoxide dismutase activity,h ave been discovered. [4,[19][20][21][22][23] TheF enton or Fenton-like reactions are widely used to explain the catalytic mechanism of peroxidase mimics.T he generated COH can be used for the degradation of organic pollutants and in the treatment of cancer, as well as in biosensing applications. [24] Another catalytic mechanism of peroxidase mimics,w hich occurs in Prussian blue and its cyanometalate structural analogues,i st he electron transfer effects.…”

Nanozymes: a new choice for disease treatment

“…因此, 在杀菌的同 时破坏生物膜或抑制生物膜的再生是促进伤口愈合和 抗伤口感染的重要策略. Yan和Liu课题组 [56] 合成了一 图 7 AMP NRs介导热疗的作用机理 [45] (网络版彩图) Figure 7 Schematic illustration of AMP NRs mediated PTT [45] (color online) (网络版彩图) Figure 8 Design and antibacterial mechanism of the 2D MOF/GOx hybrid nanocatalyst as a benign and self-activated cascade reagenta [52] (color online) 图 9 MoS 2 纳米水凝胶的合成过程及其在抗菌和促进伤口 愈合中的作用机理 [58] (网络版彩图) Figure 9 Synthesis of MoS 2 nanohydrogel and its mechanism in antibacterial and wound healing [58] (color online) [61] (网络版彩图) Figure 10 Mechanisms of dextran-coated iron oxide nanoparticles in the treatment of dental caries [61] (color online) 以MOF-AuNPs纳米杂 化物为放射增敏平台, 并在其内包载阿霉素, 实现了放 图 11 基于PtFe@Fe 3 O 4 纳米酶的光增强肿瘤催化治疗原 理 [66] (网络版彩图) Figure 11 Schematic of the photo-enhanced tumor catalytic therapy based on the PtFe@Fe 3 O 4 nanozyme [66] (color online)…”

When Nanozymes Meet Single‐Atom Catalysis

“…In addition, the atomic composition and structural complexity of nanomaterials endow a diverse range of nanozyme catalytic mechanisms. For example, many transition‐metal‐based nanozymes, such as Fe 3 O 4 , MnO 2 , V 2 O 5 , MoS 2 , and so on, with intrinsic peroxidase, oxidase, catalase, and superoxide dismutase activity, have been discovered . The Fenton or Fenton‐like reactions are widely used to explain the catalytic mechanism of peroxidase mimics.…”