Construction of Mn–N–C nanoparticles with multienzyme-like properties and photothermal performance for the effective treatment of bacterial infections

Abstract

In this work, novel Mn–N–C NPs were developed for antibacterial therapy with a photothermal-enhanced synergistic enzymatic mechanism. The bactericidal rate was 99.3% against MRSA and 98.7% against AREC, with a high wound healing efficiency.

Nanoarchitectonics of Bimetallic Cu-/Co-Doped Nitrogen–Carbon Nanozyme-Functionalized Hydrogel with NIR-Responsive Phototherapy for Synergistic Mitigation of Drug-Resistant Bacterial Infections

“…Moreover, it has been documented that metal-doped nitrogen−carbon (NC) nanomaterials possess large specific surface areas, uniform nitrogen doping, and adjustable structure. 24,25 The charge distribution of the coterminous C atoms can be influenced by N doping, strengthening the electron donation capacity of the carbon structure and increasing the spin density. This allows the activity of metal atoms to be further excited, which in turn increases the catalytic activity of metal nanozymes.…”

“…Given the fact that the POD-like activity of Cu-based nanozymes is mediated by a Fenton-like reaction, we will construct bimetallic CuCo-based nanomaterials and suspect that the POD-like activity can be improved by a dual mechanism, including the direct oxidative process of Co 3+ and the Fenton-like reaction based on Cu + . Moreover, it has been documented that metal-doped nitrogen–carbon (NC) nanomaterials possess large specific surface areas, uniform nitrogen doping, and adjustable structure. , The charge distribution of the coterminous C atoms can be influenced by N doping, strengthening the electron donation capacity of the carbon structure and increasing the spin density. This allows the activity of metal atoms to be further excited, which in turn increases the catalytic activity of metal nanozymes …”