Construction of mesoporous silica nanodrug delivery system using chitooligosaccharide (CHO) for irinotecan delivery
Jiashen Fan,
Han Song,
Shengkai Liu
et al.
Abstract:In this study, mesoporous silica nanoparticles (MSNs) around of 50 nm with high specific surface area and pore volume were synthesized using chitooligosaccharide (CHO) as a template. The specific surface area and total pore volume of the as-synthesized MSNs is 1,443.7 m2g-1 and 2.17 cm3g-1, respectively. The anticancer drug irinotecan (CPT-11) was then efficiently loaded onto the MSNs. The surface of the drug loaded MSNs was further modified by the folic acid conjugated chitosan layer to enhance theirs target … Show more
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