Construction of mannose-modified polyethyleneimine-block-polycaprolactone cationic polymer micelles and its application in acute lung injury

Su, Meiling; Hu, He-Ping; Zhao, Xuan; Huang, Chengyuan; Yang, Baocheng; Yin, Zongning

doi:10.1007/s13346-021-00976-9

Cited by 8 publications

(8 citation statements)

References 56 publications

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“…The UiO-66 NPs without DA (UiO-66) lacking defectiveness were used as a control . As mannose-functionalized nanocarriers are effective in lung-specific drug delivery, , we further prepared mannosylated HP-UiO-66 (MHP-UiO-66) NPs by attaching the aldehyde group of mannose with the amino group in HP-UiO-66 (Figure A), aiming to enhance its pulmonary localization and cellular uptake efficiency of the functional materials. As shown in the scanning electron microscopy (SEM), the UiO-66 and mannose-modified UiO-66 (M-UiO-66) NPs both formed regular octahedrons, suggesting that the mannosylation reaction had no obvious influence on the shape of the UiO-66 NPs (Figure B,C).…”

Section: Resultsmentioning

confidence: 99%

Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis

Cui

Zhang

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Bleomycins (BLMs) are widely used in clinics as antitumor agents. However, BLM-based chemotherapies often accompany severe pulmonary fibrosis (PF). Human bleomycin hydrolase is a cysteine protease that can convert BLMs into inactive deamido-BLMs. In this study, mannose-modified hierarchically porous UiO-66 (MHP-UiO-66) nanoparticles (NPs) were used to encapsulate the recombinant human bleomycin hydrolase (rhBLMH). When rhBLMH@MHP-UiO-66 was intratracheally instilled into the lungs, the NPs were transported into the epithelial cells, and rhBLMH prevented the lungs from PF during BLM-based chemotherapies. Encapsulation of rhBLMH in the MHP-UiO-66 NPs protects the enzyme from proteolysis in physiological conditions and enhances cellular uptake. In addition, the MHP-UiO-66 NPs significantly enhance the pulmonary accumulation of intratracheally instilled rhBLMH, thus providing more efficient protection of the lungs against BLMs during the chemotherapies.

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Section: Resultsmentioning

confidence: 99%

Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis

Cui

Zhang

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/polym14020253/s1: Figure S1. 1 Funding: This work was supported by the National Science Center, project "Amphiphilic copolymers containing polystyrene/polyglycidol blocks with varied architecture and their functionalized derivatives-synthesis, properties, and aggregation, used as carriers of enzymes", UMO-2018/29/B/ST4/02178.…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…Amphiphilic block copolymers (BCPs) have found numerous applications in various fields of science and branches of industry such as drug delivery carriers [1][2][3][4][5], bioactive agents carriers [6,7], tissue engineering materials [8], electrochemical sensors [9], polymer blends [10], polymer membranes [11], nanoreactors with embedded enzymes [12], enhanced-performance supercapacitors [13], anti-bacterial and anti-protein fouling coatings of various materials [14][15][16], surfactants systems for stabilization of various emulsions [17], and polymer solar cells [18]. The final application of copolymers is closely related to the chemical structure, architecture of macromolecules and properties of blocks components.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Hydrophilicity and Micellization of Coil-Brush Polystyrene-b-(polyglycidol-g-polyglycidol) Copolymer—Comparison with Linear Polystyrene-b-polyglycidol

et al. 2022

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In this paper, an original method of synthesis of coil–brush amphiphilic polystyrene-b-(polyglycidol-g-polyglycidol) (PS-b-(PGL-g-PGL)) block copolymers was developed. The hypothesis that their hydrophilicity and micellization can be controlled by polyglycidol blocks architecture was verified. The research enabled comparison of behavior in water of PS-b-PGL copolymers and block–brush copolymers PS-b-(PGL-g-PGL) with similar composition. The coil–brush copolymers were composed of PS-b-PGL linear core with average DPn of polystyrene 29 and 13 of polyglycidol blocks. The DPn of polyglycidol side blocks of coil–b–brush copolymers were 2, 7, and 11, respectively. The copolymers were characterized by 1H and 13C NMR, GPC, and FTIR methods. The hydrophilicity of films from the linear and coil–brush copolymers was determined by water contact angle measurements in static conditions. The behavior of coil–brush copolymers in water and their critical micellization concentration (CMC) were determined by UV-VIS using 1,6-diphenylhexa-1,3,5-trien (DPH) as marker and by DLS. The CMC values for brush copolymers were much higher than for linear species with similar PGL content. The results of the copolymer film wettability and the copolymer self-assembly studies were related to fraction of hydrophilic polyglycidol. The CMC for both types of polymers increased exponentially with increasing content of polyglycidol.

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“…Both in vitro and in vivo results demonstrated that PamHRchol/GA micelles decreased the inflammatory factor TNF-α expression, with obvious anti-inflammatory effects. Other block materials, such as polyethyleneimine (PEI) ( Su et al, 2022 ), have also been reported to modify PMS with significantly improved lung targeting ability.…”

Section: Nanomedicinementioning

confidence: 99%

Pharmacologic therapies of ARDS: From natural herb to nanomedicine

et al. 2022

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Acute respiratory distress syndrome (ARDS) is a common critical illness in respiratory care units with a huge public health burden. Despite tremendous advances in the prevention and treatment of ARDS, it remains the main cause of intensive care unit (ICU) management, and the mortality rate of ARDS remains unacceptably high. The poor performance of ARDS is closely related to its heterogeneous clinical syndrome caused by complicated pathophysiology. Based on the different pathophysiology phases, drugs, protective mechanical ventilation, conservative fluid therapy, and other treatment have been developed to serve as the ARDS therapeutic methods. In recent years, there has been a rapid development in nanomedicine, in which nanoparticles as drug delivery vehicles have been extensively studied in the treatment of ARDS. This study provides an overview of pharmacologic therapies for ARDS, including conventional drugs, natural medicine therapy, and nanomedicine. Particularly, we discuss the unique mechanism and strength of nanomedicine which may provide great promises in treating ARDS in the future.

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Construction of mannose-modified polyethyleneimine-block-polycaprolactone cationic polymer micelles and its application in acute lung injury

Cited by 8 publications

References 56 publications

Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis

Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis

Synthesis, Hydrophilicity and Micellization of Coil-Brush Polystyrene-b-(polyglycidol-g-polyglycidol) Copolymer—Comparison with Linear Polystyrene-b-polyglycidol

Pharmacologic therapies of ARDS: From natural herb to nanomedicine

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