Construction of indolizine scaffolds from α,ω-alkynoic acids and α,ω-vinylamines via sequential-relay catalysis in “one pot”

Abstract

A simple and efficient method for the synthesis of indolizin-3-ones through sequential Au(i)-catalyzed hydrocarboxylation, aminolysis, and cyclization, followed by ruthenium-catalyzed ring-closing metathesis.