Construction of Imidazole-Fused-Ring Systems by Iron-Catalyzed C(sp3)-H Amination–Cyclization under Aerobic Conditions
Jiangling Peng,
Shijia Li,
Junwei Huang
et al.
Abstract:An iron-catalyzed efficient C−H amination for the construction of imidazole-fused-ring systems was developed under aerobic conditions. Compared to previous studies, this work exhibited green features. The reaction was conducted in the green solvent anisole, with water as the only byproduct. Four C(sp 3 )−H bonds were cleaved and three C−N bonds were formed in this transformation. Imidazo[1,5-a]pyridine-, imidazo[5,1-b]oxazole-, imidazo[5,1-b]thiazole-, imidazo[1,5-a]pyrazine-, and imidazo-[1,5-a]imidazole-rela… Show more
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