Construction of glucose biosensor based on sorption of glucose oxidase onto multilayers of polyelectrolyte/nanoparticles

Zhang, Suxia; Yang, Weiwei; Niu, Yaming; Li, Yancai; Zhang, Ming; Sun, Chang Q.

doi:10.1007/s00216-005-0190-7

Cited by 41 publications

(26 citation statements)

References 28 publications

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“…Their bimolecular rate constants for FADH 2 -GOx oxidation range from 3 × 10 4 to 8 × 10 6 M -1 s -1 . 148 The most intensively studied ferrocene-derivatives are ferrocenemethanol 88,90,91,[149][150][151][152][153][154][155][156][157][158][159][160][161] and ferrocenecarboxylic acid. 155,[162][163][164] Several of the ferrocenes meet the requirements for application in blood-glucose analyzers, which include high solubility in water, fast electron-shuttling, stability, and pH-independence of the redox potential.…”

Section: Metal-organic Mediatorsmentioning

confidence: 99%

Electrochemical Glucose Sensors and Their Applications in Diabetes Management

2008

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About 6,000 peer reviewed articles have been published on electrochemical glucose assays and sensors, of which 700 were published in the 2005-2006 two-year period. Their number makes a full review of the literature, or even of the most recent advances, impossible. Nevertheless, this review should acquaint the reader with the fundamentals of the electrochemistry of glucose and provide a perspective of the evolution of the electrochemical glucose assays and monitors helping diabetic people, who constitute about 5% of the world's population. Because of the large number of diabetic people, no assay is performed more frequently than that of glucose. Most of these assays are electrochemical. The reader interested also in nonelectrochemical assays used in, or proposed for, the management of diabetes is referred to a 2007 review of Kondepati and Heise. 1 Adam Heller was born in 1933. Surviving the Holocaust, he arrived in Israel in 1945. He received his M.Sc. in Chemistry and Physics in 1957, then his PhD in Organic Chemistry in 1961 from Ernst David Bergman at the Hebrew University in Jerusalem. He postdoced at UC Berkeley (1962-3) and at Bell Laboratories . At GTE Labs (1964-1975 he built the first Nd 3+ liquid laser and, with J. J. Auborn, the still worldwide used Li/SOCl 2 battery. At Bell Labs (1975)(1976)(1977)(1978)(1979)(1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988) he designed the first >10% efficient electrochemical solar cells and the first >10% efficient hydrogengenerating solar-powered photoelectrode. He also headed Bell Labs' Electronic Materials Research Department (1977)(1978)(1979)(1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988), which developed part of the high density chip interconnection technology underlying the miniaturization of portable electronic devices. He was appointed to the Ernest Cockrell Sr. Chair in Engineering of the University of Texas at Austin in 1988, and in 2001 became one of UT's first Research Professors. At UT he pioneered the electrical wiring of enzymes. In 1996 he cofounded with his son Ephraim Heller TheraSense Inc., now part of Abbott Diabetes Care, to improve the lives of diabetic people. The company introduced in 2000 the blood sugar monitor FreeStyle, a thin-layer microcoulometer utilizing only 300 nL of blood, so little that it was, for the first time, painlessly obtained. In 2007 it provided for more than 1 billion painless glucose assays. After alleviating the pain of diabetes monitoring, FreeStyle Navigator, based on the electrical wiring of glucose oxidase, introduced in 2007 in Europe and Israel and in 2008 in the U.S., removed the worry of diabetic people by continuously monitoring their glucose levels. Heller aims his work at alleviating suffering through bioelectrochemistry.

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Section: Metal-organic Mediatorsmentioning

confidence: 99%

Electrochemical Glucose Sensors and Their Applications in Diabetes Management

2008

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“…Incorporation of nanomaterials such as gold nanoparticles was demonstrated to enhance sensitivity of the LbL sensors. Zhang et al used adsorption processes of enzymes with the non-enzymatic LbL layers [195]. They first prepared LbL films using poly(diallyldimethylammonium chloride) (PDDA) and gold nanoparticles on a gold electrode, and incubation of this electrode resulted in absorption of GOD into the LbL films.…”

Section: Inclusion Of Functional Nanomaterialsmentioning

confidence: 99%

Enzyme-Encapsulated Layer-by-Layer Assemblies: Current Status and Challenges Toward Ultimate Nanodevices

Ariga

Hill

2010

Advances in Polymer Science

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Alternate layer-by-layer (LbL) adsorption has received much attention as an emerging methodology. Biocompatibility is the most prominent advantage of the LbL assembly process because the technique employs mild conditions for film construction. Most enzymes, especially water-soluble ones, have charged sites at their surfaces so that electrostatic LbL adsorption is suitable for construction of various protein organizations. In this review chapter, we summarize recent developments on enzyme-encapsulated LbL devices and their related functions where "encapsulated" does not always entail entrapment within spherical structures but generally includes immobilization of enzymes within the LbL structures. Recent examples, with various functions such as reactor sensors and medical applications, are described within a classification of structural types, i.e., thin films and spherical capsules. In addition to conventional applications, advanced systems including integration of LbL structures into advanced devices such as microchannels, field effect transistors, and flow injection amperometric sensors are introduced as well as recent developments in hybridization of LbL assemblies with functional nanomaterials such as carbon nanotube, dendrimers, nanoparticles, lipid assemblies, and mesoporous materials, all of which can enhance bio-related functions of LbL assemblies.

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“…Only those LBL films with appropriate constituents can demonstrate good permeability toward some specific proteins and effectively load them under suitable conditions [16,19,20]. For instance, Sun and coworkers [21] constructed LBL films assembled by gold nanoparticles (GNPs) and poly(diallyldimethylammonium) (PDDA) on electrode surface. When the {PDDA/GNPs} n /PDDA films were immersed into GOD solutions, GOD could be loaded into the films and used to electrocatalyze the oxidation of glucose in the presence of ferrocenemethanol mediator.…”

Section: Introductionmentioning

confidence: 99%