Construction of functionalized ruthenium-modified selenium coated with pH-responsive silk fibroin nanomaterials enhanced anticancer efficacy in hepatocellular cancer

Li, Xiang; Xie, Shujie; Shen, Jia; Chen, Shuhuai; Jia, Yan

doi:10.1016/j.procbio.2022.08.029

Cited by 1 publication

(2 citation statements)

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“…PDT is a photochemistry‐based technology that uses light irradiation to activate a photosensitizing agent to generate singlet oxygen ( 1 O 2 ) from oxygen 29–31 . New methylene blue (NMB), one of the phenothiazine derivatives, has excellent antibacterial and antitumor effects 32,33 . However, the use of liquid form application on wounds presents several drawbacks, including uneven distribution, difficulty in retention, limited time for contact with the affected area, and imprecise dosage 34 .…”

Section: Introductionmentioning

confidence: 99%

“…[29][30][31] New methylene blue (NMB), one of the phenothiazine derivatives, has excellent antibacterial and antitumor effects. 32,33 However, the use of liquid form application on wounds presents several drawbacks, including uneven distribution, difficulty in retention, limited time for contact with the affected area, and imprecise dosage. 34 Thus, the development of NMB wound dressing is necessary to overcome such limitations and enhance the antibacterial effectiveness of PDT.…”

mentioning

confidence: 99%

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Wound microenvironment‐responsive peptide hydrogel with multifunctionalities for accelerating wound healing

Dong,

Yang,

Liu

et al. 2024

Journal of Peptide Science

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The fabrication of wound microenvironment‐responsive peptide hydrogels with hemostatic ability, antibacterial activity, and wound healing potential remains a challenge. Herein, we constructed a multifunctional dressing by inducing the self‐assembly of a peptide (Pep‐1) and water‐soluble new methylene blue (NMB) through electrostatic interaction. The self‐assembly mechanism was demonstrated using a combination of transmission electron microscopy, circular dichroism spectrum, fluorescence spectrum, Zeta potential, and rheological analysis. The Pep‐1/NMB hydrogel also exhibited a faster drug release rate in wound acidic environment. Furthermore, when Pep‐1/NMB was exposed to a 635 nm laser, its antibacterial ratios increased sharply to 95.3%, indicating remarkably improved antibacterial effects. The findings from the blood coagulation and hemostasis assay indicated that Pep‐1/NMB effectively enhanced the speed of blood clotting in vitro and efficiently controlled hemorrhage in a mouse liver hemorrhage model. Meanwhile, hemolytic and cytotoxicity evaluation revealed that the hydrogel had excellent hemocompatibility and cytocompatibility. Finally, the findings from the wound healing studies and H&E staining indicated that the Pep‐1/NMB hydrogel had a significant impact on cell migration and wound repair. The results indicated that wound microenvironment‐responsive Pep‐1/NMB hydrogel had significant potential as a highly effective wound dressing platform, offering rapid hemostasis, antibacterial, and wound healing acceleration properties.

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Section: Introductionmentioning

confidence: 99%