Construction of efficient electrochemiluminescence resonance energy transfer sensor based on SnO2/SnS2QDs-Ru@IRMOF-3 composite for sensitive detection of procalcitonin

Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

“…Their unique optical and electronic properties, including high brightness, photostability, broad absorption spectrum, tunable emission spectrum and distinctive photoelectrochemical activity, contribute to their effectiveness [90]. When integrated into functionalized sensing systems, QDs can successfully detect various inflammation biomarkers, such as CRP [91], PCT [92] and TNF-α [93], showing great potential for diagnosing and monitoring inflammation. For instance, Cai et al constructed a photoelectrochemical biosensor for ultra-sensitive "on-off" detection of inflammation biomarkers: TNF-α and methylase (MTase) [93].…”

Aggregation-Induced Electrochemiluminescence Based on a Zinc-Based Metal–Organic Framework and a Double Quencher Au@UiO-66-NH2 for the Sensitive Detection of Amyloid β 42 via Resonance Energy Transfer

“…Electrochemiluminescence (ECL) occurs due to electrochemical and chemiluminescence reactions on electrode surfaces or near the surface of the electrode. ECL has attracted wide attention for clinical diagnosis and drug analysis due to its low background, high sensitivity, and high controllability. − Several novel ECL concepts have emerged in the last few years. Aggregation-induced emission (AIE) is an interesting phenomenon discovered by Tang and his colleagues that overcomes the obstacle due to aggregation-caused quenching (ACQ). − To prevent ACQ, Tang and his colleagues modified ACQ nuclei with AIE molecules to distort the structure of the ACQ nuclei and destroy the molecular planarity to suppress π–π stacking.…”

Electrochemiluminescence resonance energy transfer between a Ru-ZnMOF self-enhanced luminophore and a double quencher ZnONF@PDA to detect NSE

“…Various procedures for immobilizing Ru(bpy) 3 2+ in aqueous media have been explored. 24 For example, Ru(bpy) 3 2+ was fixed by electrostatic interactions, 25 agitated adsorption, 26 encapsulation, 27 and coordination reaction. 28,29 Polydopamine (PDA) is a bionic polymer with excellent coating performance, significant biocompatibility, and good biodegradability.…”