Construction of Diverse Fused Chromene Frameworks via Isocyanide-Based Three-Component Reaction
Yu-Wei He,
Li Huang,
Kun Huang
et al.
Abstract:A convenient synthetic protocol for diverse fused chromenes was successfully developed by a three-component reaction of alkyl isocyanides, dialkyl but-2-ynedioates, and various cyclic 1,3-dipolarophiles containing o-hydroxyphenyl group. In the absence of any catalyst, the three-component reaction of alkyl isocyanides, dialkyl but-2-ynedioates, and 3-(o-hydroxyarylidene)indolin-2-ones in tetrahydrofuran at 60 °C resulted in unique functionalized spiro [cyclobuta[c]chromene-1,3′-indolines] in good yields and wit… Show more
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