Construction of CNA35 Collagen-Targeted Phase-Changeable Nanoagents for Low-Intensity Focused Ultrasound-Triggered Ultrasound Molecular Imaging of Myocardial Fibrosis in Rabbits

Zhou, Qin; Zeng, Yalin; Xiong, Qingsong; Zhong, Shigen; Li, Pan; Ran, Haitao; Yin, Yuehui; Reutelingsperger, Chris; Prinze, Frits W.; Ling, Zhiyu

doi:10.1021/acsami.9b05999

Cited by 19 publications

(20 citation statements)

References 52 publications

(61 reference statements)

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“…Zhou et al . designed an US-based multifunctional CNA35-labeled perfluoropentane nanoparticles (CNA35-PFP NPs) and injected them intravenously into a rabbit model of MI ( Zhou et al, 2019 ). It was found that CNA35-PFP NPs can effectively cross the interstitial space of endothelial cells and adhere to the surface of fibroblasts.…”

Section: Nanomaterials-mediated Diagnosis Strategies For MImentioning

confidence: 99%

“…Combining the unique advantages of US imaging with nanomaterials and attaching specific molecular markers to the surface of nano materials enables these nano scale contrast agents to target MI-specific antigens or antibodies. Zhou et al designed an US-based multifunctional CNA35-labeled perfluoropentane nanoparticles (CNA35-PFP NPs) and injected them intravenously into a rabbit model of MI (Zhou et al, 2019). It was found that CNA35-PFP NPs can effectively cross the interstitial space of endothelial cells and adhere to the surface of fibroblasts.…”

Section: Nanomaterials-enhanced Cardiac Imagingmentioning

confidence: 99%

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Nanomaterials-Mediated Therapeutics and Diagnosis Strategies for Myocardial Infarction

et al. 2022

Front. Chem.

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The alarming mortality and morbidity rate of myocardial infarction (MI) is becoming an important impetus in the development of early diagnosis and appropriate therapeutic approaches, which are critical for saving patients’ lives and improving post-infarction prognosis. Despite several advances that have been made in the treatment of MI, current strategies are still far from satisfactory. Nanomaterials devote considerable contribution to tackling the drawbacks of conventional therapy of MI by improving the homeostasis in the cardiac microenvironment via targeting, immune modulation, and repairment. This review emphasizes the strategies of nanomaterials-based MI treatment, including cardiac targeting drug delivery, immune-modulation strategy, antioxidants and antiapoptosis strategy, nanomaterials-mediated stem cell therapy, and cardiac tissue engineering. Furthermore, nanomaterials-based diagnosis strategies for MI was presented in term of nanomaterials-based immunoassay and nano-enhanced cardiac imaging. Taken together, although nanomaterials-based strategies for the therapeutics and diagnosis of MI are both promising and challenging, such a strategy still explores the immense potential in the development of the next generation of MI treatment.

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Section: Nanomaterials-mediated Diagnosis Strategies For MImentioning

confidence: 99%

Section: Nanomaterials-enhanced Cardiac Imagingmentioning

confidence: 99%

Nanomaterials-Mediated Therapeutics and Diagnosis Strategies for Myocardial Infarction

et al. 2022

Front. Chem.

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“…Apart from EP‐3533, gold (Au) nanoparticles have also been explored for targeted imaging of collagen. Zhou et al [ 73 ] constructed CNA35‐labeled perfluoropentane nanoparticles. These nanoparticles could specifically target fibroblasts and collagen.…”

Section: Nanomedicines Targeting Extracellular Matrixmentioning

confidence: 99%

Advances on Nanomedicines for Diagnosis and Theranostics of Hepatic Fibrosis

Dai

Zeng

Zhang

et al. 2021

Advanced NanoBiomed Research

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Hepatic fibrosis is induced by chronic hepatic injuries before it turns into hepatic cirrhosis/carcinoma. It is characterized by the formation of collagen and other extracellular matrices around damaged hepatic tissues; consequently, the normal architecture of liver would be disrupted and its function impaired. Diagnosis of hepatic fibrosis, especially at the early stage, is crucial because most fibrotic changes are reversible during the hepatic fibrosis stage. However, early and more accurate diagnosis of hepatic fibrosis still remains a great challenge. With their promising structural adjustability and targeting ability, nanomedicines have recently been introduced to improve diagnosis of hepatic fibrosis. By targeting fibrogenic cells, receptors, and extracellular matrix components, these nanomedicines can achieve detection of hepatic tissues with high sensitivity and specificity at the early stage. The use of nanomedicines can also enable theranostics of this chronic hepatic disease. This review aims to present an overview of recent advances of nanomedicines in diagnosis and theranostics of hepatic fibrosis.

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“…Anaplastic thyroid carcinoma (ATC) is one of the most malignant carcinomas, though it is comparatively rare, characterized by fast proliferation, neck invasion, and remote metastasis (Zhu et al, 2018;Zhong et al, 2019;Zhou et al, 2019;. The severe prognosis that accompanies ATC is due to the rapid progression of tumors before diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Precise engineering of cetuximab encapsulated gadollium nanoassemblies: in vitro ultrasound diagnosis and in vivo thyroid cancer therapy

Qi¹,

Gao²,

Nie³

et al. 2021

Drug Delivery

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We report the formulation of nanoassemblies (NAs) comprising C225 conjugates Gd-PFH-NAs (C-Gd-PFH-NAs) for low-intensity focused ultrasound diagnosis ablation of thyroid cancer. C-Gd-PFH-NAs showed excellent stability in water, phosphate-buffered saline (PBS), and 20% rat serum. Transmission electron microscopy (TEM) images also revealed the effective construction of C-Gd-PFH-NAs as common spherical assemblies. The incubation of C625 thyroid carcinoma with C-Gd-PFH-NAs triggers apoptosis, as confirmed by flow cytometry analysis. The C-Gd-PFH-NAs exhibited antitumor efficacy in human thyroid carcinoma xenografts, where histopathological results further confirmed these outcomes. Furthermore, we were able to use low-intensity focused ultrasound diagnosis imaging (LIFUS) to examine the efficiency of C-Gd-PFH-NAs in thyroid carcinoma in vivo. These findings clearly show that the use of LIFUS agents with high performance imaging in different therapeutic settings will have extensive potential for future biomedical applications.

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Construction of CNA35 Collagen-Targeted Phase-Changeable Nanoagents for Low-Intensity Focused Ultrasound-Triggered Ultrasound Molecular Imaging of Myocardial Fibrosis in Rabbits

Cited by 19 publications

References 52 publications

Nanomaterials-Mediated Therapeutics and Diagnosis Strategies for Myocardial Infarction

Nanomaterials-Mediated Therapeutics and Diagnosis Strategies for Myocardial Infarction

Advances on Nanomedicines for Diagnosis and Theranostics of Hepatic Fibrosis

Precise engineering of cetuximab encapsulated gadollium nanoassemblies: in vitro ultrasound diagnosis and in vivo thyroid cancer therapy

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