Construction of blood compatible chitin/graphene oxide composite aerogel beads for the adsorption of bilirubin

Song, Xingguo; Huang, Xiuhong; Li, Zhixiong; Li, Zhentao; Wu, Keke; Jiao, Yanpeng; Zhou, Changren

doi:10.1016/j.carbpol.2018.12.005

Cited by 71 publications

(28 citation statements)

References 45 publications

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“…Hemolysis is another topic related to the hemocompatibility of biomaterials in contact with blood, the hemolysis ratio is an important parameter for evaluating blood compatibility. The lower the hemolysis rate, the better the blood compatibility of the material, and there have recently been some reports of carbon nanomaterials with excellent hemocompatibility [9,10,11,12] and high adsorption capacity [13,14].…”

Section: Introductionmentioning

confidence: 99%

Graphene Nanoplatelets Modified with Amino-Groups by Ultrasonic Radiation of Variable Frequency for Potential Adsorption of Uremic Toxins

Cabello-Alvarado

Andrade-Guel²,

Pérez-Álvarez

et al. 2019

Nanomaterials

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Chronic kidney disease (CKD) is a worldwide public health problem. In stages III and IV of CKD, uremic toxins must be removed from the patient by absorption, through a treatment commonly called hemodialysis. Aiming to improve the absorption of uremic toxins, we have studied its absorption in chemically modified graphene nanoplatelets (GNPs). This study involved the reaction between GNPs and diamines with reaction times of 30, 45 and 60 min using ultrasound waves of different amplitudes and frequencies. Functionalized GNPs were analyzed by Fourier Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), Scanning electron microscopy and energy dispersitive spectroscopy (SEM-EDS), and Thermogravimetric analysis (TGA). The analysis of the functional groups confirmed the presence of amide and hydroxyl groups on the surface of the GNPs by reactions of diamines with carboxylic acids and epoxides. Adsorption of uremic toxins was determined using equilibrium isotherms, where the maximum percentage of removal of uremic toxins was 97%. Dispersion of modified graphene nanoplatelets was evaluated in water, ethanol and hexane, as a result of this treatment was achieved a good and effective dispersion of diamines-modified graphene nanoplatelets in ethanol and hexane. Finally, the results of hemolysis assays of the modified graphene with amine demonstrated that it was not cytotoxic when using 500 mg/mL. The samples of modified graphene demonstrated low degree of hemolysis (<2%), so this material can be used for in vivo applications such as hemodialysis.

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Section: Introductionmentioning

confidence: 99%

Graphene Nanoplatelets Modified with Amino-Groups by Ultrasonic Radiation of Variable Frequency for Potential Adsorption of Uremic Toxins

Cabello-Alvarado

Andrade-Guel²,

Pérez-Álvarez

et al. 2019

Nanomaterials

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“…In summary, films, beads, fibers, intragastric floating tablets, microspheres, and chitin/chitosan nanoparticles and their derivatives have been formulated for use in the pharmaceutical field. Recent findings even support their potential for gene therapy applications [ 7 , 40 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ].…”

Section: Chitin/chitosan Matrices Provide the Potential For Multiple ...mentioning

confidence: 96%

Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

Behr

Ganesan

2022

Materials

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Improved wound healing of burnt skin and skin lesions, as well as medical implants and replacement products, requires the support of synthetical matrices. Yet, producing synthetic biocompatible matrices that exhibit specialized flexibility, stability, and biodegradability is challenging. Synthetic chitin/chitosan matrices may provide the desired advantages for producing specialized grafts but must be modified to improve their properties. Synthetic chitin/chitosan hydrogel and aerogel techniques provide the advantages for improvement with a bioinspired view adapted from the natural molecular toolbox. To this end, animal genetics provide deep knowledge into which molecular key factors decisively influence the properties of natural chitin matrices. The genetically identified proteins and enzymes control chitin matrix assembly, architecture, and degradation. Combining synthetic chitin matrices with critical biological factors may point to the future direction with engineering materials of specific properties for biomedical applications such as burned skin or skin blistering and extensive lesions due to genetic diseases.

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“…For instance, chitin with glucan and polyphenols from pomegranate recovered endothelial dysfunction by reducing inflammatory marker in the liver and adipose tissues and promoting NO synthase in apolipoprotein E deficient mice (apoE−/−) with high fat diet [59]. Furthermore, chitin combined to graphene oxide as aerogel beads effectively absorbed excessive bilirubin in the blood [60]. Chitin nanogel with rectorite nanocomposite stopped bleeding within 121 s in rat tail vein, and promoted higher hemostatic activity compared to chitosan-based hemostatic products [61].…”

Section: Cardiovascular and Hematological Diseasesmentioning

confidence: 99%

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

Satitsri

Muanprasat

2020

Molecules

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Chitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of N-acetyl-glucosamine and d-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed.

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Construction of blood compatible chitin/graphene oxide composite aerogel beads for the adsorption of bilirubin

Cited by 71 publications

References 45 publications

Graphene Nanoplatelets Modified with Amino-Groups by Ultrasonic Radiation of Variable Frequency for Potential Adsorption of Uremic Toxins

Graphene Nanoplatelets Modified with Amino-Groups by Ultrasonic Radiation of Variable Frequency for Potential Adsorption of Uremic Toxins

Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

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