Construction of bionanoparticles based on Angelica polysaccharides for the treatment of stroke

Su, Yanguo; Guo, Caixia; Chen, Qiang; Guo, Huimin; Wang, Jinqiu; Mu, Kaihang; Chen, Daquan

doi:10.1016/j.nano.2022.102570

Cited by 7 publications

(8 citation statements)

References 26 publications

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“…Benefiting from the inflammatory chemotaxis capacity of macrophage membranes and their ability to infiltrate into deep tissue, macrophage/monocyte-based nanoparticles were mainly designed to abate the inflammation in IS. For instance, Chen et al [ 99 ] utilized modern Chinese medicine and constructed macrophage membrane-based ROS-reactive nanoparticles to target inflammatory microenvironment. Altogether, these biomimetic nanoparticles encapsulated with anti-inflammatory reagents exert therapeutic effects attributing to two strategies: reducing the inflammatory infiltration from periphery and inhibiting the immunological cascade in ischemic focal site.…”

Section: Cell Membrane-based Nanoparticles For Is Treatmentmentioning

confidence: 99%

Biomimetic nanoparticles in ischemic stroke therapy

Liu

Xiao

et al. 2023

Discover Nano

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Ischemic stroke is one of the most severe neurological disorders with limited therapeutic strategies. The utilization of nanoparticle drug delivery systems is a burgeoning field and has been widely investigated. Among these, biomimetic drug delivery systems composed of biogenic membrane components and synthetic nanoparticles have been extensively highlighted in recent years. Biomimetic membrane camouflage presents an effective strategy to prolong circulation, reduce immunogenicity and enhance targeting. For one thing, biomimetic nanoparticles reserve the physical and chemical properties of intrinsic nanoparticle. For another, the biological functions of original source cells are completely inherited. Compared to conventional surface modification methods, this approach is more convenient and biocompatible. In this review, membrane-based nanoparticles derived from different donor cells were exemplified. The prospect of future biomimetic nanoparticles in ischemic stroke therapy was discussed. Graphic abstract

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Section: Cell Membrane-based Nanoparticles For Is Treatmentmentioning

confidence: 99%

Biomimetic nanoparticles in ischemic stroke therapy

Liu

Xiao

et al. 2023

Discover Nano

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“…After administration, it was found that MAOE@TMP specifically delivered drugs to the site of brain injury and exerted neuroprotective and ROS scavenging effects. Finally, it reversed the inflammatory microenvironment, protected the damaged brain tissue, and significantly reduced the area of cerebral infarction . In another experiment, the researchers prepared macrophage-modified manganese dioxide(MnO 2 ) nanoparticles loaded with FTY (Ma@(MnO 2 +FTY)).…”

Section: Nanometer Materialsmentioning

confidence: 99%

“…Finally, it reversed the inflammatory microenvironment, protected the damaged brain tissue, and significantly reduced the area of cerebral infarction. 83 In another experiment, the researchers prepared macrophage-modified manganese dioxide(MnO 2 ) nano-particles loaded with FTY (Ma@(MnO 2 +FTY)). Macrophagemembrane protein mediated the recognition of cell adhesion molecules overexpressed by injured vascular endothelial cells, thus leading to the accumulation of Ma@ (MnO 2 +FTY) in the brain.…”

Section: Nanometer Materialsmentioning

confidence: 99%

Application of Nanotechnology-Based Products in Stroke

Cai

Sun

Chen

et al. 2023

ACS Chem. Neurosci.

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Stroke is a disease with high disability and high mortality in the world. Due to the existence of the blood-brain barrier (BBB), complex brain structure, and numerous neural signal pathways, the treatment methods are limited, so new drugs and new treatments need to be developed urgently. Thankfully, the advent of nanotechnology offered a new opportunity for biomedical development because of the unique properties of nanoparticles that give them the ability to traverse the BBB and accumulate in relevant regions of the brain. More importantly, nanoparticles could be modified on the surface to meet a variety of specific properties that people need. Some could be used for effective drug delivery, including tissue plasminogen activator (tPA), neuroprotective agents, genes, and cytokines; some nanoparticles were used as contrast agents and biosensors in medical imaging for further diagnosis of stroke; some were used to track target cells for prognosis of stroke; and some were used to detect pathological markers of stroke that appear at different stages. This Review looks at the application and research progress of nanoparticles in the diagnosis and treatment of stroke, hoping to bring some help to researchers.

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“…Su et al utilized biologically active Angelica polysaccharide as the hydrophilic end, and linked ethyl ferulate to the ROS-responsive oxalate bond, forming ROS-responsive nanocores, which were then camouflaged with macrophage membrane. This approach achieved targeted delivery of the biologically active macromolecules to brain thrombosis [ 89 ].…”

Section: Cell Membrane-derived Nanovehicles With a Core-shell Structurementioning

confidence: 99%

“…Therefore, clearing ROS is an effective strategy in thrombus treatment. Su et al developed a macrophage membrane-based ROS-responsive nanoparticle system for targeting the inflammatory microenvironment using modern herbal medicine [ 89 ]. Fu et al synthesized functionalized azo-bridged L-ascorbic acid nanocomposites (CZ NCs) by reacting zoledronic acid with cerium ions, which were then enveloped by the thrombocyte membrane to serve as a new carrier for the drug probucol [ 85 ].…”

Section: Application Of Cell Membrane-derived Nanovehicles In the Tre...mentioning

confidence: 99%

Cell Membrane-Derived Nanovehicles for Targeted Therapy of Ischemic Stroke: From Construction to Application

Hao,

Sha,

et al. 2023

Pharmaceutics

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Ischemic stroke (IS) is a prevalent form of stroke and a leading cause of mortality and disability. Recently, cell membrane-derived nanovehicles (CMNVs) derived from erythrocytes, thrombocytes, neutrophils, macrophages, neural stem cells, and cancer cells have shown great promise as drug delivery systems for IS treatment. By precisely controlling drug release rates and targeting specific sites in the brain, CMNVs enable the reduction in drug dosage and minimization of side effects, thus significantly enhancing therapeutic strategies and approaches for IS. While there are some reviews regarding the applications of CMNVs in the treatment of IS, there has been limited attention given to important aspects such as carrier construction, structural design, and functional modification. Therefore, this review aims to address these key issues in CMNVs preparation, structural composition, modification, and other relevant aspects, with a specific focus on targeted therapy for IS. Finally, the challenges and prospects in this field are discussed.

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Construction of bionanoparticles based on Angelica polysaccharides for the treatment of stroke

Cited by 7 publications

References 26 publications

Biomimetic nanoparticles in ischemic stroke therapy

Biomimetic nanoparticles in ischemic stroke therapy

Application of Nanotechnology-Based Products in Stroke

Cell Membrane-Derived Nanovehicles for Targeted Therapy of Ischemic Stroke: From Construction to Application

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