Construction of axially chiral compounds via catalytic asymmetric radical reaction

Selective Three-Component 1,2-Aminoalkoxylation of 1-Aryl-1,3-dienes by Dual Photoredox and Copper Catalysis

“…Despite these significant advances in the area of 1,2-aminooxygenation of 1,3-dienes, it is still an attractive but challenging task to expand the scope of nitrogen and oxygen functional groups that are easily manipulable. With a resurgence of interest in the field of synthetic radical chemistry, radical-mediated transformation of 1,3-dienes has developed into a powerful tool for the construction of various diversely substituted allylic compounds . Therefore, we hypothesized that the exploration of suitable radical precursors and catalytic activation methods might offer more opportunities to realize three-component 1,2-aminooxygenation reactions of 1,3-dienes, in spite of the only report developed by Wang …”

N-Heterocyclic Carbene-Catalyzed Remote Enantioselective C–C Bond Formation via 1,6-Addition with Formyl Enynes

“…Atropisomeric compounds have attracted substantial attention recently due to their wide applications in natural product chemistry, catalyst or ligand design, and drug discovery . Central-to-axial chirality transfer represents an efficient strategy for the construction of axially chiral compounds .…”

Transition-metal-catalyzed atroposelective synthesis of axially chiral styrenes

“…Radical-involved atroposelective bifunctionalization of alkynes for the construction of axially chiral styrenes was also realized by the Zhang group in 2022 (Scheme 24). 70,71 Assisted by pyridoxazolin L21 , multifarious C–C axially chiral styrenes bearing both electron-donating and electron-withdrawing groups at various positions were obtained via Ni-catalyzed three component radical coupling. For deep insight into the detailed mechanism, DFT calculations were performed on the basis of evidence supplied by electron paramagnetic resonance (EPR) experiments.…”