Construction of Angularly Fused Tricyclic Compounds via Photo-induced Radical Cascade Cyclization

Abstract

A photo-triggered cascade cyclization of silyl enolate to prepare angularly fused tricyclic scaffold is developed. The reaction demonstrates good substrate scope and stereo-selectivity. The excellent stereo- and regio-selectivity for this cascade reaction is elucidated via conformational analysis and DFT calculation, respectively.