Construction of an Engineered Escherichia coli with Efficient Chemotactic and Metabolizing Ability toward Tetrathionate
Xin-Ge Wang,
Zhen-Ping Zou,
Yue Du
et al.
Abstract:The
emergence of genetically engineered bacteria has provided a
new means for the diagnosis and treatment of diseases. However, in
vivo applications of these engineered bacteria are hindered by their
inefficient accumulation in areas of inflammation. In this study,
we constructed an engineered Escherichia coli (E. coli) for directional migration
toward tetrathionate (a biomarker of gut inflammation), which is regulated
by the TtrSR two-component system (TCS) from Shewanella
baltica OS195 (S. baltica). Specific… Show more
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