“…Additional expression of a sucrose porin (cscY) and a sucrose operon repressor (cscR) further improved sucrose utilization (Löwe et al, 2020), while further optimization of the nitrogen-deficiency response pathway (Hobmeier et al, 2020) and culture conditions could boost PHA titer further (Kratzl et al, 2023; Table 2). Other co-culture products include the metabolites ethylene, isoprene, 3-hydroxypropionic acid (3-HP), and 2,3-butanediol (Table 2), which are compounds in a broader class of industrially relevant precursors widely used for chemical synthesis (e.g., diols, organic acids, gaseous alkenes; Cui et al, 2022;Li C. et al, 2022;Ma et al, 2022). In most of these reports, the heterotrophic microbe utilized were E. coli substrains, although the rapidly growing halophile Vibrio natriegens was able to produce a relatively high amount of 2,3-butanediol in co-culture (Li C. et al, 2022).…”