Construction of a UV cell for micro‐liquid chromatography

Kientz, Ch.E.; Verweij, A.

doi:10.1002/jhrc.1240110316

Cited by 25 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, its detection and analysis are the hardest among the CWAs because of its largely reduced vapor pressure and slight chemical instability. As a result, although it can be analyzed under standard gas chromatographic conditions, 25,26 it is sometimes converted to its G analog for easier or faster analysis. 27 The problem of VX analysis is further exacerbated by its extreme toxicity.…”

Section: The Critical Issue Of Vx Analysismentioning

confidence: 99%

Fast GC-PFPD system for field analysis of chemical warfare agents

Frishman

Amirav

2000

Field Analyt. Chem. Technol.

View full text Add to dashboard Cite

A fast gas chromatograph (GC) equipped with a pulsed‐flame photometric detector (PFPD) was designed and built with the intention of facilitating field analysis of the full range of chemical warfare agents (CWA). This GC‐PFPD system was tested with five organophosphorus and organosulfur CWA simulants that cover the volatility range of common CWA. Fast repetitive analysis was demonstrated with a cycle time as short as 30 s, combined with very low detection limits of 20 ng/m3 for organophosphorus CWA simulants and 200 ng/m3 for organosulfur compounds. With a longer analysis time of 80 s, a 3‐ng/m3 detection limit was demonstrated for DMMP. In the GC‐PFPD system, the separation power of each of these techniques is orthogonal and independent; thus, this hyphenated combination is characterized by a very low false‐alarm rate, combined with CWA identification capability at the molecular level. The large improvement in system selectivity is demonstrated in the direct analysis of a low level of triethylphosphate in the headspace of diesel fuel without any interference. The system inlet was heated and the sample path was inert without any metal, enabling fast response time and low detection limits for a low volatility agent such as VX. The same fast GC‐PFPD system could also be quickly and easily switched to a continuous sampling “sniff” mode of operation with 2‐s response time. Alternatively, it could be operated in a novel mode of thermally modulated inlet (TMI) that provided intermediate results between those of GC and “sniff” in terms of the trade‐off of response time and performance. The fast GC‐PFPD system is also characterized by low average hydrogen consumption (about 4 ml/min), small size, and low weight. No attempt was made to complete the system in terms of portable control electronics. The advantages and unique features of this system, as well as the importance of CWA identification at the molecular level, are discussed. © 2000 John Wiley & Sons, Inc. Field Analyt Chem Technol 4: 170–194, 2000

show abstract

Section: The Critical Issue Of Vx Analysismentioning

confidence: 99%

Fast GC-PFPD system for field analysis of chemical warfare agents

Frishman

Amirav

2000

Field Analyt. Chem. Technol.

View full text Add to dashboard Cite

show abstract

“…detector cell -and is brought into the light path of a UV absorbance detector. The construction of such a cell has been discussed [135,136]. Vindevogel et al [137] developed design guidelines for tubular UV absorbance detection flow cells.…”

Section: Uv Absorbance Detectionmentioning

confidence: 99%

Microcolumn liquid chromatography: instrumentation, detection and applications

Vissers¹,

Claessens

Cramers

1997

Journal of Chromatography A

208

101

View full text Add to dashboard Cite

This review discusses many different aspects of microcolumn liquid chromatography (LC) and reflects the areas of microcolumn LC research interest over the past decades. A brief theoretical discussion on a number of major issues, such as column characterisation, chromatographic dilution effects and extracolumn band broadening in microcolumn LC is given. Recent progress in column technology and the demands and developments of instrumentation and accessories for microcolumn LC are also reviewed. Besides that, the developments in a large number of established and also more recent detection techniques for microcolumn LC are also discussed. The potential of hyphenation of microcolumn LC with other techniques, more particularly of multidimensional chromatography and microcolumn LC coupled to mass spectrometry is reviewed. Finally, the perspective of microcolumn LC separation methods is stressed by a number of relevant applications.

show abstract

“…The differences between the electron impact ionization spectra of the derivatized isomeric compounds are not very significant, and hence identification becomes more tedious. Several analytical methods for the analysis of the chemical warfare agents and their degradation products from different environmental matrices have been reviewed recently 3,4…”

mentioning

confidence: 99%

Mass spectral studies of N,N‐dialkylaminoethanols

Reddy

Mirza

Saradhi

et al. 2003

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

Some dialkylaminoethanols, precursors of chemical warfare agents such as V-agents and nitrogen mustards, were analyzed by electron impact (EI) and electrospray ionization (ESI) mass spectrometry. The fragmentation pathways in EI and ESI-MS/MS methods are rationalized. The collision-induced dissociation (CID) spectra of [M+H](+) ions of aminoethanols in ESI mode are clearly distinguishable from one another, including those of isomeric normal and branched chain dialkylaminoethanols. Structures can be proposed based on the general fragmentation pathways of these molecules.

show abstract

Construction of a UV cell for micro‐liquid chromatography

Cited by 25 publications

References 8 publications

Fast GC-PFPD system for field analysis of chemical warfare agents

Fast GC-PFPD system for field analysis of chemical warfare agents

Microcolumn liquid chromatography: instrumentation, detection and applications

Mass spectral studies of N,N‐dialkylaminoethanols

Contact Info

Product

Resources

About