Construction of a ratio fluorescence assay of 5-aminosalicylic acid based on its aggregation induced emission with blue emitting N/P-codoped carbon dots

Abstract

Herein, a novel ratio fluorescence method based on N/P-doped carbon dots (NPCDs) for detecting 5-aminosalicylic acid (5-ASA) in mesalazine enteric coated tablets and blood were reported for the first time.

Recent advances in aggregation-induced emission (AIE)-based chemosensors for the detection of organic small molecules

“…Yue et al prepared carbon dots ( B43 ) via one-step hydrothermal synthesis from ATP and p -toluidine which emits bright blue fluorescence at 423 nm with a PLQY of 20.75%. 220 Significant blue emission enhancement was observed when 5-ASA, an inflammatory bowel disease treatment drug with weak emission at 487 nm, was added to B43 . This was attributed to the formation of aggregate between the two compounds, leading to the AIE of 5-ASA and ratiometric increase in intensity of 5-ASA's 487 nm emission relative to B43 's 423 nm emission.…”

Carbonized polymer dots for the sensitive and selective analysis of chlortetracycline based on the aggregation induced emission

“…4B), representing C-C/CQC and C-O/C-N bonds, respectively. [34][35][36] The HRXPS of N1s is divided into three peaks at 398.6 eV (pyridine-N), 399.0 eV (-NH 2 ), and 399.3 eV (graphite-N) 37,38 (Fig. 4C).…”