Construction of a new multi-turn time-of-flight mass spectrometer

Toyoda, Michisato; Ishihara, Morio; Yamaguchi, S.; Ito, Hiroyuki; Matsuo, T.; Roll, R.; Rosenbauer, H.

doi:10.1002/(sici)1096-9888(200002)35:2<163::aid-jms924>3.0.co;2-g

Cited by 43 publications

(32 citation statements)

References 9 publications

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“…e doublet peaks observed at 1029.7, with a 0.03 u di erence, are enlarged. e third peak of (0, 17) and the monoisotopic ion peak of (4,14) can be seen to be clearly resolved owing to the high mass resolving power of 80,000 for this system. In contrast, no (4, 14) peak was e mass spectrum of the EO-PO block copolymer at m/z 1,027.2-1,033.2. e solid arrows indicate the isotopic pattern of (0, 17), and the dotted arrows indicate that of (4,14).…”

Section: Resultsmentioning

confidence: 90%

“…e solid arrows indicate an isotopic pattern of (0, 17), and the dotted arrows point to that of (4,14). e doublet peaks observed at 1029.7, with a 0.03 u di erence, are enlarged.…”

Section: Resultsmentioning

confidence: 99%

“…We have adopted an ion optical system that employs a spiral ion trajectory [8][9][10] (SpiralTOF) rather than the more commonly used ion mirror. is system is based on a multi-turn ion optical system that uses electrostatic sectors, [11][12][13][14][15][16] in particular the "MULTUM II" system developed at Osaka University, Japan. 15,16) In a previous report we discussed the basic performance of this system 10) and con rmed that a superior mass resolution and mass accuracy could be successfully achieved over a wide mass range.…”

Section: Introductionmentioning

confidence: 99%

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Separation of Isobaric Compounds Using a Spiral Orbit Type Time-of-Flight Mass Spectrometer, MALDI-SpiralTOF

et al. 2014

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e development of a MALDI-TOF mass spectrometer that utilizes spiral ion trajectory, SpiralTOF, is reported. e total ight path length was 17 m, which is ve times longer than that in commonly used re ectron ion optical system. e SpiralTOF reduced the dependence of the mass resolving power on the mass of the analyte, while improving the accuracy of the mass measurements. Furthermore, SpiralTOF has two advantages that can be exploited for the separation of minor abundant isobaric components in mass spectra. One is the reduction in chemical background due to the post source decay (PSD), which is achieved through PSD ion elimination by electrostatic sectors contained within the SpiralTOF. e other is that the stabilities of peak positions are improved during mass spectrum accumulation. e peak dri caused by the ne structure of matrix crystals and the small irregularities on the sample surface can be reduced by extending the ight path. In this study, these advantages are demonstrated via the analysis of a block copolymer and mass spectrometry imaging (MSI) of lipids.

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Section: Resultsmentioning

confidence: 90%

“…e solid arrows indicate an isotopic pattern of (0, 17), and the dotted arrows point to that of (4,14). e doublet peaks observed at 1029.7, with a 0.03 u di erence, are enlarged.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Separation of Isobaric Compounds Using a Spiral Orbit Type Time-of-Flight Mass Spectrometer, MALDI-SpiralTOF

et al. 2014

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“…The proposed systems are listed as follows: Figure 1 shows the development history of multi-turn TOF mass spectrometers at Osaka University. We designed and constructed the first multi-turn TOF mass spectrometer "MULTUM Linear plus" as a laboratory model for cometary exploration (Matsuo et al, 1999;Toyoda et al, 2000;Toyoda et al, 2003). The system consists of four discrete units, each comprised of an electrostatic quadrupole lens, a cylindrical electrostatic sector and an electrostatic quadrupole lens.…”

Section: A Few Issues For Miniaturized Mass Spectrometersmentioning

confidence: 99%

Miniaturized Mass Spectrometer in Analysis of Greenhouse Gases: The Performance and Possibilities

Shimma¹,

Toyoda²

2012

Greenhouse Gases - Emission, Measurement and Management

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“…Recently, several new multi-turn TOF mass spectrometers have been constructed in Japan. Sakurai et al designed and constructed a fairly large multi-turn TOF mass spectrometer referred to as "OVAL" [10] comprising six electrostatic analyzers that produced an elliptical orbit of 7.4 m. Almost simultaneously, a compact multi-turn TOF mass spectrometer referred to as "MULTUM linear plus" [11] was developed at the Osaka University. It consisted of four cylindrical electrostatic sectors and 16 electrostatic quadrupole lenses.…”

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confidence: 99%

The design and characteristic features of a new time-of-flight mass spectrometer with a spiral ion trajectory

Satoh

Tsuno

Iwanaga

et al. 2005

J. Am. Soc. Mass Spectrom.

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A new time-of-flight (TOF) mass spectrometer with a corkscrew ion trajectory was designed and constructed. The spiral trajectory was realized by using four toroidal electrostatic sectors. Each had fifteen-stories made of sixteen Matsuda plates piled up inside a cylindrical electrostatic sector. The ions passed the four toroidal electrostatic sectors sequentially and revolved along a figure-eight-shaped orbit on a certain projection plane. During the multiple revolutions, each ion trajectory was shifted by 50 mm per cycle on a direction perpendicular to the projection plane, thus generating a spiral trajectory. The flight path length of one cycle was 1.308 m so that the maximum flight path length became ϳ20 m. The mass resolution, mass accuracy, and ion transmission were tested by utilizing an orthogonally coupled electron ionization source. A mass resolution of 35,000 (FWHM) for m/z greater than 300 was achieved. Even in a lower mass region, mass resolutions of more than 20,000 (FWHM) were confirmed with a doublet of 12 C 5 1 H 5 14 N ϩ and 13 C 12 C 5 1 H 6 ϩ . The mass accuracy was also improved such that it was better than 1 ppm with only one internal standard peak. . With the advent of matrix-assisted laser desorption/ionization (MALDI) [3,4] and electrospray ionization (ESI) techniques [5], the TOF mass spectrometer has become a powerful analytical tool, especially in biochemistry and biotechnology. Its characteristic features are high sensitivity, theoretically infinite massrange, and rapid measurements. It also provides a simple and easy method to obtain exact mass measurements. These features give the TOF mass spectrometer a great advantage over other mass spectrometers, such as the quadrupole, ion trap, and magnetic sector-type mass spectrometers. However, a drawback of the TOF mass spectrometer is the intrinsic characteristic of poor mass resolving power for accurate mass analysis, especially for small molecules, compared with a Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometer. In an orthogonal acceleration (oa-) TOF mass spectrometer, the mass resolution and mass accuracy are limited to approximately 10,000 (FWHM) and 3 ppm, respectively. On the other hand, in the FT-ICR mass spectrometer, they have reached over 100,000 (FWHM) and 1 ppm, respectively.The mass resolution of the TOF mass spectrometer is expressed as R ϭ m/⌬m ϭ t/2⌬t, where t is the total time of flight, which is given by the flight path length divided by the ion velocity, and ⌬t is the peak width measured at FWHM. Thus, it is essential to extend the flight path length and minimize the peak width to improve the mass resolution. The peak width depends on the broadening of the ion packet at the detector, especially along the velocity axis and the response time of the detector. Various ion optical techniques have been reported to minimize the peak width: space focusing [6], time-lag focusing [6], orthogonal acceleration [7], and an ion mirror [8] or sector fields [9]. The mass accuracy can be steadily improved by increas...

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Construction of a new multi-turn time-of-flight mass spectrometer

Cited by 43 publications

References 9 publications

Separation of Isobaric Compounds Using a Spiral Orbit Type Time-of-Flight Mass Spectrometer, MALDI-SpiralTOF

Separation of Isobaric Compounds Using a Spiral Orbit Type Time-of-Flight Mass Spectrometer, MALDI-SpiralTOF

Miniaturized Mass Spectrometer in Analysis of Greenhouse Gases: The Performance and Possibilities

The design and characteristic features of a new time-of-flight mass spectrometer with a spiral ion trajectory

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