Construction of a large Stokes shift fluorescent probe for dual detection of mitochondrial viscosity and ONOO− and its application in bioimaging

Highly selective and sensitive surface-enhanced Raman scattering sensors for the detection of peroxynitrite in cells

“…Based on S/N = 3, the detection limit is 0.48 μM ( I 981 / I 993 ), which is comparable with that in some previous work. 50,51 The results demonstrate that the Au NF/MAPE probe studied can recognize trace ONOO − , which provides a possibility for further detection of ONOO − in cells.…”

“…In addition, an abnormally high level of ONOO − is also related to many diseases, such as neurodegenerative diseases, 8,9 inflammatory infections, 10,11 liver injury diseases, 12,13 and even cancer, 14 as well as influencing the endoplasmic reticulum viscosity. 15,16…”

“…In addition, an abnormally high level of ONOO − is also related to many diseases, such as neurodegenerative diseases, 8,9 inflammatory infections, 10,11 liver injury diseases, 12,13 and even cancer, 14 as well as influencing the endoplasmic reticulum viscosity. 15,16 At present, several methods for detecting ONOO − have been reported, such as near-infrared spectroscopy, 17,18 high-performance liquid chromatography, 19 chemiluminescence, 20 fluorescence spectroscopy, [21][22][23] ultraviolet-visible absorption spectroscopy, 24 electron spin resonance 25,26 and electrochemistry. 27,28 Although there have been a few reports on SERS methods for detecting intracellular ONOO − , 29 the reasons of ONOO − causing organisms lesions have not well explained yet.…”