Construction of a hierarchical micro &amp; nanoporous surface for loading genistein on the composite of polyetheretherketone/tantalum pentoxide possessing antibacterial activity and accelerated osteointegration

Mei, Shiqi; Hu, Xinglong; Kong, Yang; Xie, Dong; Yang, Lili; Wu, Zhaoying

doi:10.1039/d0bm01306d

Cited by 32 publications

(22 citation statements)

References 44 publications

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“…Antibiosis and anti‐inflammation can eliminate cough‐related incentives, and dilation of blood vessels can help dilute irritants in the blood, thereby reducing the cough (Xue‐jian et al, 2011). Among the core antitussive components obtained, quercetin, genistein, luteolin, kaempferol and emodin have explicit antibacterial, anti‐inflammatory and vasodilatory effects (Dong et al, 2016; Jaiswal et al, 2019; Li et al, 2016; Mei et al, 2021; Ren et al, 2019; Wu et al, 2020). Quercetin can relieve acute lung injury induced by cigarettes, and has a significant antitussive effect when combined with mangiferin (da Silva Araújo et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Integration of UPLC–QE–MS/MS and network pharmacology to investigate the active components and action mechanisms of tea cake extract for treating cough

Lin

Liu

Chen

et al. 2022

Biomedical Chromatography

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The active components and mechanisms of tea cake extract (TCE) were investigated for treating cough. The components of TCE were tentatively identified by ultrahighperformance liquid chromatography coupled with Q-Exactive MS/MS (UPLC-QE-MS/MS), whose targets were obtained from the Swiss Target Prediction database and the Traditional Chinese Medicine Systems Pharmacology database and analysis platform. Cough-related targets were retrieved from the Gene Cards and Online Mendelian Inheritance in Man database. After the intersection targets had been obtained, enrichment analysis of Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were determined, and the protein-protein interaction network and active compound-intersection target-KEGG pathway network were constructed. Core active compounds and their targets were validated with molecular docking. A total of 78 compounds were identified from TCE, including 24 flavonoids, 17 phenolic acids, 10 alkaloids, seven organic acids, five triterpenes, five amino acids, five coumarins, three carbohydrates, one anthraquinone and one other. A total of 347 intersection targets were obtained. The top five GO terms with the most significant P-values were responses to oxygen-containing compounds and organic substances, chemical and cellular responses to chemical stimulus, and regulation of biological quality. The top five KEGG pathways with the most significant Pvalues were: the PI3K-Akt signaling pathway, lipids and atherosclerosis, human cytomegalovirus infection, fluid shear stress and atherosclerosis, and proteoglycans in cancer. The top five core active compounds were quercetin, genistein, luteolin, kaempferol and emodin. The top five core targets were protein kinase B (Akt1), prostaglandin-endoperoxide synthase 2 (PTGS2), mitogen-activated protein kinase 1/3 (MAPK1/3) and phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1). The top five core active compounds could stably bind to their targets with LibDockScores higher than 100. Tea cake extract plays the antitussive role via multiple components and targets. Core targets (AKT1, MAPK1, MAPK3 and PIK3R1) and core components (quercetin, genistein, luteolin and kaempferol) involved in the PI3K-Akt signaling pathway are worth more attention in subsequent validation experiments.

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Section: Discussionmentioning

confidence: 99%

Integration of UPLC–QE–MS/MS and network pharmacology to investigate the active components and action mechanisms of tea cake extract for treating cough

Lin

Liu

Chen

et al. 2022

Biomedical Chromatography

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“…Mei et al loaded GT on the 3D network structure of tantalum pentoxide and PEEK composites, obtained by concentrated sulfuric acid sulfonation. The antibacterial rates of the GT loaded materials were 88.2% against S. aureus and 100% against E. coli , indicating that GT‐loaded material had a significant antibacterial effect on S. aureus and E. coli 26 …”

Section: Antibacterial Coatingmentioning

confidence: 99%

“…The antibacterial rates of the GT loaded materials were 88.2% against S. aureus and 100% against E. coli, indicating that GT-loaded material had a significant antibacterial effect on S. aureus and E. coli. 26…”

Section: Genisteinmentioning

confidence: 99%

Modification strategies for improving antibacterial properties of polyetheretherketone

Gao

Han

et al. 2022

J of Applied Polymer Sci

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Polyetheretherketone (PEEK) is a semi‐crystalline thermoplastic polymer that has been gradually used in the repair of bone defects because of its well chemical stability, reliable biocompatibility, excellent X‐ray radiolucency, and low modulus. However, PEEK is a biologically inert material, and planktonic bacteria can adhere to its surface and eventually form biofilms, allowing for the rapid development of implant‐related infections. This review mainly introduces two important antibacterial modification strategies: antibacterial coating and surface morphology modification. Antibacterial coating include antibiotics, natural extracts, antimicrobial peptides, polymers, metals and metal oxides, selenium, fluoride, silicon nitride, and graphene oxide. These coatings can exert their antibacterial effect by inhibiting bacterial adhesion, killing bacteria by contact, or actively releasing antimicrobial substances. In terms of antibacterial surface topography, different surface microstructures have their respective antibacterial functions. Conical or cylindrical structures can exert stress on the bacterial surface causing the rupture of the cell membrane to kill bacteria. Nano protrusions or particles smaller than the size of bacteria can inhibit the adhesion of bacteria by reducing the contact area of bacteria and PEEK. The pit structure close to the size of bacteria can prevent the contact between adjacent bacteria and delay or prevent the formation of biofilm.

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“…Cell experiments demonstrated that when compared with PN, the adhesion, proliferation, and osteogenic differentiation of rBMSCs on SPN and SPNG were enhanced. In animal experiments, SPN and SPNG had greater bone formation than PN [ 205 ].…”

Section: Anti-infective Functionmentioning

confidence: 99%

“… [ 203 ] Concentrated sulfuric acid, Ta, GS In vitro : TPSG exhibits excellent antibacterial properties; increased cytocompatibility and differentiation of MG-63 cell; In vivo : enhanced bone regeneration and osseointegration [ 86 ] NTP, concentrated sulfuric acid, GS In vitro : Cytocompatibility and differentiation increased gradually in PN, SPN, and SPNG; showed excellent antibacterial activity on SPNG; In vivo : bone formation was successively enhanced in PN, SPN, and SPNG. [ 205 ] Coating antibiotics CaHPO 4 ·2H 2 O, GS In vitro : increased cytocompatibility and differentiation; had incredible antibacterial properties; In vivo : exhibited excellent antibacterial activity and osteointegration in femoral defect infection of rat experiments. [ 211 ] GS, SF, AgNPs In vitro : increased cytocompatibility and differentiation; had remarkable antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants

Zheng

Liu

Zhang

et al. 2022

Materials Today Bio

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Construction of a hierarchical micro & nanoporous surface for loading genistein on the composite of polyetheretherketone/tantalum pentoxide possessing antibacterial activity and accelerated osteointegration

Abstract: Nanoporous tantalum pentoxide (NTP) particles with pore size of around 10 nm were synthesized and blended with polyetheretherketone (PEEK) to fabricate PEEK/NTP composite (PN). Subsequently, PN was treated by concentrated...

Cited by 32 publications

References 44 publications

Integration of UPLC–QE–MS/MS and network pharmacology to investigate the active components and action mechanisms of tea cake extract for treating cough

Integration of UPLC–QE–MS/MS and network pharmacology to investigate the active components and action mechanisms of tea cake extract for treating cough

Modification strategies for improving antibacterial properties of polyetheretherketone

Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants

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