Construction of a Glycaemia-Based Signature for Predicting Acute Kidney Injury in Ischaemic Stroke Patients after Endovascular Treatment

Liu, Chengfang; Li, Xiaohui; Xu, Zhaohan; Wang, Yishan; Jiang, Teng; Wang, Meng; Deng, Qiwen; Zhou, Junshan

doi:10.3390/jcm11133865

Cited by 5 publications

(4 citation statements)

References 43 publications

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“…In this retrospective study, the authors enrolled 717 acute ischemic stroke patients who had undergone endovascular treatment, of whom 205 (28.6%) experienced acute renal injury. At the end of the study, the SHR value was shown to be an independent predictor of the development of acute renal injury (OR: 4.455, 95% CI: 2.237−8.871, p < 0.001) [ 24 ]. In our study, we obtained the mABG value from the blood glucose values at three different times perioperatively in the EVAR procedure that we planned as elective intervention, and we determined the mSHR value based on this parameter.…”

Section: Discussionmentioning

confidence: 99%

The Roles of Liver Fibrosis Scores and Modified Stress Hyperglycemia Ratio Values in Predicting Contrast-Induced Nephropathy after Elective Endovascular Infrarenal Abdominal Aortic Aneurysm Repair

et al. 2023

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Endovascular aortic repair (EVAR) methods are higher preferred for the treatment of patients with abdominal aortic aneurysms (AAAs). Various markers, including the neutrophil-lymphocyte ratio, have been used to predict the risk of contrast-induced nephropathy (CIN). In this study, we aimed to investigate the role of fibrosis-4 score (FIB-4), aspartate transaminase to platelet ratio index (APRI), and modified stress hyperglycemia ratio (mSHR) values in predicting CIN. Patients who had undergone elective endovascular infrarenal abdominal aortic aneurysm repair in our clinic between January 2015 and January 2022 were included in this retrospective study. Patients who did not develop contrast-induced nephropathy after the procedure were identified as Group 1, and those who did were referred to as Group 2. A total of 276 patients were included in the study. The two groups were similar in terms of age, gender, body mass index, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, hyperlipidemia, and left ventricular ejection fraction. In Group 2, the FIB-4 score, APRI, and mSHR values were significantly higher (p = 0.008, p < 0.001, and p < 0.001, respectively). In Group 2, the contrast volume and number of packed blood products used (median 1 (1–4) vs. 2 (1–5)) were significantly higher (p = 0.003 and p = 0.012, respectively). In this study, we demonstrated that we may predict the risk of CIN development with preoperatively calculated, noninvasive liver fibrosis scores and mSHR.

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Section: Discussionmentioning

confidence: 99%

The Roles of Liver Fibrosis Scores and Modified Stress Hyperglycemia Ratio Values in Predicting Contrast-Induced Nephropathy after Elective Endovascular Infrarenal Abdominal Aortic Aneurysm Repair

et al. 2023

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“…The model has good discriminatory power, with area under the ROC curve values of 0.756 and 0.760 in the training and validation cohorts, respectively. Recently, Liu et al constructed a glycemic-based predictive model for predicting the occurrence of AKI in stroke patients treated with endovascular treatment (EVT) to provide evidence for the glycemic management of patients ( 24 ). They screened stroke patients receiving EVT and included many glycemic-related factors, such as acute glycemia, hemoglobin bA1c (HbA1c), and average chronic glycemia, from the perspective of glycemic management.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the prediction model was also developed to predict the risk of AKI in patients with diabetic ketoacidosis. The predictors used to construct the nomogram included diabetes, obesity, simplified acute (24). They screened stroke patients receiving EVT and included many glycemic-related factors, such as acute glycemia, hemoglobin bA1c (HbA1c), and average chronic glycemia, from the perspective of glycemic management.…”

Section: Discussionmentioning

confidence: 99%

Dynamic nomogram for predicting acute kidney injury in patients with acute ischemic stroke: A retrospective study

Zhu

Jin

et al. 2022

Front. Neurol.

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BackgroundThis study sought to develop and validate a dynamic nomogram chart to assess the risk of acute kidney injury (AKI) in patients with acute ischemic stroke (AIS).MethodsThese data were drawn from the Medical Information Mart for Intensive Care III (MIMIC-III) database, which collects 47 clinical indicators of patients after admission to the hospital. The primary outcome indicator was the occurrence of AKI within 48 h of intensive care unit (ICU) admission. Independent risk factors for AKI were screened from the training set using univariate and multifactorial logistic regression analyses. Multiple logistic regression models were developed, and nomograms were plotted and validated in an internal validation set. Based on the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) to estimate the performance of this nomogram.ResultsNomogram indicators include blood urea nitrogen (BUN), creatinine, red blood cell distribution width (RDW), heart rate (HR), Oxford Acute Severity of Illness Score (OASIS), the history of congestive heart failure (CHF), the use of vancomycin, contrast agent, and mannitol. The predictive model displayed well discrimination with the area under the ROC curve values of 0.8529 and 0.8598 for the training set and the validator, respectively. Calibration curves revealed favorable concordance between the actual and predicted incidence of AKI (p > 0.05). DCA indicates the excellent net clinical benefit of nomogram in predicting AKI.ConclusionIn summary, we explored the incidence of AKI in patients with AIS during ICU stay and developed a predictive model to help clinical decision-making.

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“…Moreover, brain aneurysms and ruptured arteriovenous malformation (AVM) can cause cerebral hemorrhages and are associated with increased morbidity and mortality, especially in young individuals [ 7 , 8 ]. Instead, cerebral ischemia is caused by a clot-induced interruption of blood flow triggering hypoxic conditions and nutrient deprivation of the cerebral tissue [ 9 , 10 , 11 , 12 ]. The lack of cerebral blood supply induces a massive necrosis and an irreversible neuronal damage that prompts a significant release of glutamate with consequent hyperactivation of the N-methyl-D-Aspartate (NMDA) receptors.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular and Neuronal Consequences of Thyroid Hormones Alterations in the Ischemic Stroke

et al. 2022

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Ischemic stroke is one of the leading global causes of neurological morbidity and decease. Its etiology depends on multiple events such as cardiac embolism, brain capillaries occlusion and atherosclerosis, which ultimately culminate in blood flow interruption, incurring hypoxia and nutrient deprivation. Thyroid hormones (THs) are pleiotropic modulators of several metabolic pathways, and critically influence different aspects of tissues development. The brain is a key TH target tissue and both hypo- and hyperthyroidism, during embryonic and adult life, are associated with deranged neuronal formation and cognitive functions. Accordingly, increasing pieces of evidence are drawing attention on the consistent relationship between the THs status and the acute cerebral and cardiac diseases. However, the concrete contribution of THs systemic or local alteration to the pathology outcome still needs to be fully addressed. In this review, we aim to summarize the multiple influences that THs exert on the brain and heart patho-physiology, to deepen the reasons for the harmful effects of hypo- and hyperthyroidism on these organs and to provide insights on the intricate relationship between the THs variations and the pathological alterations that take place after the ischemic injury.

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Construction of a Glycaemia-Based Signature for Predicting Acute Kidney Injury in Ischaemic Stroke Patients after Endovascular Treatment

Cited by 5 publications

References 43 publications

The Roles of Liver Fibrosis Scores and Modified Stress Hyperglycemia Ratio Values in Predicting Contrast-Induced Nephropathy after Elective Endovascular Infrarenal Abdominal Aortic Aneurysm Repair

The Roles of Liver Fibrosis Scores and Modified Stress Hyperglycemia Ratio Values in Predicting Contrast-Induced Nephropathy after Elective Endovascular Infrarenal Abdominal Aortic Aneurysm Repair

Dynamic nomogram for predicting acute kidney injury in patients with acute ischemic stroke: A retrospective study

Cardiovascular and Neuronal Consequences of Thyroid Hormones Alterations in the Ischemic Stroke

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