Construction of a comprehensive nutritional index and comparison of its prognostic performance with the PNI and NRI for survival in older patients with nasopharyngeal carcinoma: a retrospective study

Duan, Yuyu; Deng, Jun; Su, Dongfang; Li, Wen-Qiong; Yuan, Han; Li, Zhen-Xiu; Huan, Xue-Zhen; Zhu, Shiheng; Yang, Qiulan; Hu, Wen; Xin, Ming-Zhu; Tang, Lin‐Quan; Fan, Yun; He, Yan

doi:10.1007/s00520-021-06128-6

Cited by 9 publications

(8 citation statements)

References 32 publications

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“…The second study, which included 124 patients with head and neck cancer—20 of whom had NPC—found that low post-treatment PNI levels significantly indicated poor prognoses [ 56 ]. The third study, specifically targeting patients with NPC, linked lower PNI levels immediately post treatment with poorer survival outcomes [ 26 ]. Similarly, the fourth study, assessing the PNI one month post treatment in patients with NPC, confirmed this association.…”

Section: Discussionmentioning

confidence: 99%

“…For patients with NPC, increasing evidence has demonstrated that a low PNI is associated with poorer survival outcomes in both the short and long term [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Previous research has predominantly focused on the pre-treatment PNI, although some studies have also examined the post-treatment levels [ 26 , 27 ]. Whether evaluating pre- or post-treatment PNIs, these studies have relied on isolated measurements taken at specific timepoints, neglecting the extensive longitudinal PNI data gathered during routine post-treatment surveillance.…”

Section: Introductionmentioning

confidence: 99%

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A Joint Model Based on Post-Treatment Longitudinal Prognostic Nutritional Index to Predict Survival in Nasopharyngeal Carcinoma

Hsiao,

Wang,

et al. 2024

Cancers

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Background: a low PNI in patients with NPC is linked to poor survival, but prior studies have focused on single-timepoint measurements. Our study aims to employ joint modeling to analyze longitudinal PNI data from each routine visit, exploring its relationship with overall survival. Methods: In this retrospective study using data from the Chang Gung Research Database (2007–2019), we enrolled patients with NPC undergoing curative treatment. We analyzed the correlation between patient characteristics, including the PNI, and overall survival. A joint model combining a longitudinal sub-model with a time-to-event sub-model was used to further evaluate the prognostic value of longitudinal PNI. Results: A total of 2332 patient were enrolled for the analysis. Separate survival analyses showed that longitudinal PNI was an independent indicator of a reduced mortality risk (adjusted HR 0.813; 95% CI, 0.805 to 0.821). Joint modeling confirmed longitudinal PNI as a consistent predictor of survival (HR 0.864; 95% CI, 0.850 to 0.879). An ROC analysis revealed that a PNI below 38.1 significantly increased the risk of 90-day mortality, with 90.0% sensitivity and 89.6% specificity. Conclusions: Longitudinal PNI data independently predicted the overall survival in patients with NPC, significantly forecasting 90-day survival outcomes. We recommend routine PNI assessments during each clinic visit for these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Joint Model Based on Post-Treatment Longitudinal Prognostic Nutritional Index to Predict Survival in Nasopharyngeal Carcinoma

Hsiao,

Wang,

et al. 2024

Cancers

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“…After IMRT, lower CNI score was associated with poorer quality of life [58]. Similarly, in stage 3 and 4 elderly cancer patients with nasopharyngeal cancer, who underwent radiotherapy, CNI was used to assess the prognostic role of nutritional status, and it was found that CNI was an independent prognosticator for survival and disease-free survival [59]. In the same survey, PNI and NRI were also assessed with similar results [59].…”

Section: Nrs-2002mentioning

confidence: 98%

“…Duan 2021 [59] 187 nasopharyngeal cancer patients who had a normal nutrition before treatment modified Nutrition Index (m-NI)…”

Section: Pharyngeal Cancermentioning

confidence: 99%

“…Similarly, in stage 3 and 4 elderly cancer patients with nasopharyngeal cancer, who underwent radiotherapy, CNI was used to assess the prognostic role of nutritional status, and it was found that CNI was an independent prognosticator for survival and disease-free survival [59]. In the same survey, PNI and NRI were also assessed with similar results [59]. 2020) investigated the prognostic impact of modified Nutrition Index (m-NI) on treatment toxicity and survival in 187 nasopharyngeal cancer patients who had a normal nutrition before treatment.…”

Section: Nrs-2002mentioning

confidence: 99%

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May Nutritional Status Positively Affect Disease Progression and Prognosis in Patients with Oesophageal and Pharyngeal Cancers? A Scoping Review of the Current Clinical Studies

Psara¹,

Papadopoulou²,

Tryfonos³

et al. 2023

Preprint

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Background: Malnutrition in oesophageal and pharyngeal cancer patients constitutes a common and serious concern, which significantly reduces patients’ prognosis. Cancers of the oesophagus and the pharynx can considerably impair feeding in patients, resulting in severe undernutrition. This is a scoping review which aims to critically summarize and scrutinize the current clinical evidence on the use and prognostic role of diverse nutritional assessment tools on the prognosis of patients with oesophageal and pharyngeal cancers. Methods: PubMed, Scopus, Web of Science and Google Scholar databases were comprehensively explored utilizing relative keywords to detect clinical studies that investigate whether nutritional status may affect disease prognosis. Results: Several assessment tools have evaluated and highlighted the prognostic role of nutritional status on patients’ survival and disease complications in both oesophageal and pharyngeal cancers. Regarding oesophageal cancer, CONUT, PNI, PG-SGA and NRS-2002 are more commonly used, while albumin is also frequently evaluated. Regarding pharyngeal cancers, fewer studies are currently available. PNI has been evaluated and its significance as a factor for shorter overall survival, distant metastasis-free survival, progression-free survival, and locoregional recurrence-free has been highlighted. Comprehensive Nutritional Index has also been evaluated with positive results, as well as NRS 2002, GPS, and body weight status. However, there is currently a lack of studies with adequate female patients. There is also a significant lack of well-designed prospective studies with well-organized methodology. Conclusion: Nutritional status may significantly affect disease progression and patients’ survival, highlighting the importance of a good nutritional status in patients with oesophageal and pharyngeal cancers. Further large-scaled and well-designed prospective clinical studies are strongly recommended to verify the potential beneficial effects of nutritional status in patients with oesophageal and pharyngeal cancers.

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Prognostic nutritional index and serum lactate dehydrogenase predict the prognosis of nasopharyngeal carcinoma patients who received intensity-modulated radiation therapy

Zhang,

Zhan,

Fang

et al. 2023

J Cancer Res Clin Oncol

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Construction of a comprehensive nutritional index and comparison of its prognostic performance with the PNI and NRI for survival in older patients with nasopharyngeal carcinoma: a retrospective study

Cited by 9 publications

References 32 publications

A Joint Model Based on Post-Treatment Longitudinal Prognostic Nutritional Index to Predict Survival in Nasopharyngeal Carcinoma

A Joint Model Based on Post-Treatment Longitudinal Prognostic Nutritional Index to Predict Survival in Nasopharyngeal Carcinoma

May Nutritional Status Positively Affect Disease Progression and Prognosis in Patients with Oesophageal and Pharyngeal Cancers? A Scoping Review of the Current Clinical Studies

Prognostic nutritional index and serum lactate dehydrogenase predict the prognosis of nasopharyngeal carcinoma patients who received intensity-modulated radiation therapy

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