Construction, characterization and bioactivity evaluation of curcumin nanocrystals with extremely high solubility and dispersion prepared by ultrasound-assisted method
“…It was because the large number of nanosized Cur was released by the rapid dissolution of the carrier, a part of which dissolved immediately and formed a local saturated solution, and the remaining particles that could not be dissolved in time diffused and then dissolved under various interaction forces, such as van der Waals force, hydrophobic interaction, electrostatic interaction, hydrogen bonding and Brownian motion. 55 Therefore, the “smoke” we saw was denser near the tablet while it was filamentous in the distance, and the color of the medium turned yellow gradually with time. Figure 7 Intrinsic dissolution curves of Cur-NCs with different drug loading.…”
“…It was because the large number of nanosized Cur was released by the rapid dissolution of the carrier, a part of which dissolved immediately and formed a local saturated solution, and the remaining particles that could not be dissolved in time diffused and then dissolved under various interaction forces, such as van der Waals force, hydrophobic interaction, electrostatic interaction, hydrogen bonding and Brownian motion. 55 Therefore, the “smoke” we saw was denser near the tablet while it was filamentous in the distance, and the color of the medium turned yellow gradually with time. Figure 7 Intrinsic dissolution curves of Cur-NCs with different drug loading.…”
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