Construction and validation of a nomogram based on the log odds of positive lymph nodes to predict cancer-specific survival in patients with small cell lung cancer after surgery

Association of log odds of positive lymph nodes with survival in patients with small cell lung cancer: Results from the SEER database

“…It was reported that LODDS is a better predictor of survival than pLNs and LNR for lung cancer patients. 16 , 17 However, both this study and previous studies have reported that LODDS alone is a poor predictor (AUC < 0.70) for survival. The combination of LODDS with other clinical indicators may improve the prediction of survival in SCLC patients.…”

“…However, a recent study reported that LNR, pLNs, and LODDS were linked to survival in SCLC after surgery. 17 The inconsistent results of this study and previous studies regarding the effects of pLNs and LNR on survival in SCLC patients may be influenced by the severity of the disease. Previous studies included patients who underwent surgery, and these were usually early-stage patients, whereas in the present study 85.47% of the patients had no surgery and just 5.90% of the patients had an AJCC stage of Ⅰ/Ⅱ.…”

“… 25 , 26 Indicators for assessing the positive LNs (e.g., pLNs, LNR, and LODDS) in lung cancer patients have been proposed. 15 , 16 , 17 Yang et al showed that higher LNR values were linked to reduced OS and CSS in early-stage SCLC patients with surgically resected. 15 Deng et al indicated that pLNs, LNR, and LODDS were factors that influence survival in NSCLC patients.…”

“…For example, Chao et al developed a nomogram using LODDS, age, tumor size, sex, and radiation therapy for predicting SCLC survival with an AUC of 0.76. 17 However, prediction of survival in SCLC patients may require more research due to the high degree of risk and mortality of SCLC.…”

“… 12 , 13 Therefore, previous studies have constructed some indicators to evaluate the LN status of lung cancer, such as positive LN Ratio (LNR), pLNs, and the Log Odds of positive LNs (LODDS). 14 , 15 , 16 , 17 LNR has been used for risk stratification of lung cancer patients with prognostic value. 15 , 18 However, pLNs and LNR do not allow risk stratification of patients without positive LN metastases.…”