Construction and Validation of a Ferroptosis-Related Prognostic Model for Endometrial Cancer

Wang, Hao; Wu, Yingchen; Chen, Shengfu; Hou, Minzhi; Yang, Yanning; Xie, Mingquan

doi:10.3389/fgene.2021.729046

Cited by 14 publications

(3 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, it has been unveiled that the chemotherapy resistance of endometrial cancer is relevant to ferroptosis [ 76 ]. For Cisplatin and Paclitaxel, endometrial cancer patients with a lower score of ferroptosis commonly exhibited a higher IC50, suggesting that chemotherapy resistance is more possible to be developed in these women [ 77 ]. Does this happen to EOC patients as well?…”

Section: Discussionmentioning

confidence: 99%

Ferroptosis in epithelial ovarian cancer: a burgeoning target with extraordinary therapeutic potential

Ruan,

Wen,

Fang

et al. 2023

Cell Death Discov.

View full text Add to dashboard Cite

Epithelial ovarian cancer (EOC) is universally acknowledged as a terrifying women killer for its high mortality. Recent research advances support that ferroptosis, an emerging iron-dependent type of regulated cell death (RCD) triggered by the excessive accumulation of lipid peroxides probably possesses extraordinary therapeutic potential in EOC therapy. Herein, we firstly provide a very concise introduction of ferroptosis. Special emphasis will be put on the ferroptosis’s vital role in EOC, primarily covering its role in tumorigenesis and progression of EOC, the capability of reversing chemotherapy resistance, and the research and development of related therapeutic strategies. Furthermore, the construction of ferroptosis-related prognostic prediction systems, and mechanisms of ferroptosis resistance in EOC are also discussed. Finally, we propose and highlight several important yet unanswered problems and some future research directions in this field.

show abstract

Section: Discussionmentioning

confidence: 99%

Ferroptosis in epithelial ovarian cancer: a burgeoning target with extraordinary therapeutic potential

Ruan,

Wen,

Fang

et al. 2023

Cell Death Discov.

View full text Add to dashboard Cite

show abstract

“…A total of 21 types of cells were identified in EC samples, out of which activated CD8 T cells, eosinophils, CD56dim NK cells, and activated B cells correlated with a better EC prognosis. The analysis of differentially expressed ferroptosis genes in four clusters revealed thirteen of them, namely, TUBB4A , TMPRSS2 , STX18 , LINC01224 , SLC25A35 , CD7 , COL23A1 , ZG16B , KCNK6 , NWD1 , C11orf63 , GZMM , and NMU , as ferroptosis gene signatures [ 27 ]. Although the direct relation of these genes to EC is unclear, some of them are involved in other oncogenic diseases.…”

Section: Ferroptosis-based Prognostic Models Of Endometrial Cancermentioning

confidence: 99%

“…Commonly, a higher expression of ferroptosis genes correlates positively with immune cell infiltration into tumor mass, highlighting the importance of ferroptosis immunogenicity. Not surprisingly, ferroptosis gene signatures are used to create prognostic models for EC patient survival [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis, Metabolic Rewiring, and Endometrial Cancer

Žalytė

2023

IJMS

View full text Add to dashboard Cite

Ferroptosis is a newly discovered form of regulated cell death. The main feature of ferroptosis is excessive membrane lipid peroxidation caused by iron-mediated chemical and enzymatic reactions. In normal cells, harmful lipid peroxides are neutralized by glutathione peroxidase 4 (GPX4). When GPX4 is inhibited, ferroptosis occurs. In mammalian cells, ferroptosis serves as a tumor suppression mechanism. Not surprisingly, in recent years, ferroptosis induction has gained attention as a potential anticancer strategy, alone or in combination with other conventional therapies. However, sensitivity to ferroptosis inducers depends on the metabolic state of the cell. Endometrial cancer (EC) is the sixth most common cancer in the world, with more than 66,000 new cases diagnosed every year. Out of all gynecological cancers, carcinogenesis of EC is mostly dependent on metabolic abnormalities. Changes in the uptake and catabolism of iron, lipids, glucose, and glutamine affect the redox capacity of EC cells and, consequently, their sensitivity to ferroptosis-inducing agents. In addition to this, in EC cells, ferroptosis-related genes are usually mutated and overexpressed, which makes ferroptosis a promising target for EC prediction, diagnosis, and therapy. However, for a successful application of ferroptosis, the connection between metabolic rewiring and ferroptosis in EC needs to be deciphered, which is the focus of this review.

show abstract

Integrating ferroptosis-related genes (FRGs) and prognostic models to enhance UCEC outcome prediction and therapeutic insights

Jin,

Zhuang,

Lin

et al. 2023

J Appl Genetics

View full text Add to dashboard Cite

Construction and Validation of a Ferroptosis-Related Prognostic Model for Endometrial Cancer

Abstract: Graphical AbstractAnalysis workflow chart.

Cited by 14 publications

References 55 publications

Ferroptosis in epithelial ovarian cancer: a burgeoning target with extraordinary therapeutic potential

Ferroptosis in epithelial ovarian cancer: a burgeoning target with extraordinary therapeutic potential

Ferroptosis, Metabolic Rewiring, and Endometrial Cancer

Integrating ferroptosis-related genes (FRGs) and prognostic models to enhance UCEC outcome prediction and therapeutic insights

Contact Info

Product

Resources

About