Construction and validation of a novel prognostic nomogram for patients with sarcomatoid renal cell carcinoma: a SEER-based study

Hou, Guoqing; Li, Xian; Zheng, Yu; Liu, Pengfei; Yan, Fei; Ju, Dongen; Zhang, Geng; Zheng, Wanxiang; Gao, Ming; Hou, Niuniu; Yuan, Jiarui; Wang, Fuli; Yuan, Jianlin

doi:10.1007/s10147-020-01681-2

Cited by 12 publications

(14 citation statements)

References 22 publications

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“…5 , T stage was the most significant independent predictor, followed by N stage and tumor grade, underscoring the prognostic significance of the 2010 AJCC staging system and the International Society of Urological Pathology consensus 28 , 29 . With respect to M status, we further analyzed the specific site of metastases, which was subdivided into lung, bone, and liver with reference to the method proposed by Hou et al 30 , and all three covariates made significant contributions to the CSM, especially the occurrence of lung metastases. We thought that it could perform a more individualized prediction and surveillance of prognosis using this approach compared to others classifying patients as M0 or M1.…”

Section: Discussionmentioning

confidence: 99%

The first competing risk survival nomogram in patients with papillary renal cell carcinoma

Hou

Yang

et al. 2021

Sci Rep

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There is still a lack of competing risk analysis of patients with papillary renal cell carcinoma (pRCC) following surgery. We performed the cumulative incidence function (CIF) to estimate the absolute risks of cancer-specific mortality (CSM) and other-cause mortality (OCM) of pRCC over time, and constructed a nomogram predicting the probability of 2-, 3- and 5-year CSM based on competing risk regression. A total of 5993 pRCC patients who underwent nephrectomy between 2010 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The 2-, 3-, 5-year CSM rates were 3.2%, 4.4% and 6.5%, respectively, and that of OCM were 3.2%, 5.0% and 9.3%, respectively. The estimates of 5-year cumulative mortality were most pronounced among patients aged > 75 years in OCM (17.0%). On multivariable analyses, age, tumor grade, T stage, N stage, and with or without bone, liver and lung metastases were identified as independent predictors of CSM following surgery and were integrated to generate the nomogram. The nomogram achieved a satisfactory discrimination with the AUCt of 0.730 at 5-year, and the calibration curves presented impressive agreements. Taken together, age-related OCM is a significant portion of all-cause mortality in elderly patients and our nomogram can be used for decision-making and patient counselling.

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Section: Discussionmentioning

confidence: 99%

The first competing risk survival nomogram in patients with papillary renal cell carcinoma

Hou

Yang

et al. 2021

Sci Rep

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“…Nomograms, which are graphical representations of multivariable models that integrate several predictors, 29 have been proven to be useful in clinical settings and to perform well at predicting the individual likelihood of experiencing certain events, such as erectile function recovery after radical prostatectomy, 30 testicle salvage in patients with testicular torsion, 31 and natural conception at various time points for couples diagnosed with unexplained subfertility. 32 The present study is the first to develop an effective nomogram to assess the likelihood of achieving iCGI in patients with LPE treated with dapoxetine.…”

Section: Discussionmentioning

confidence: 99%

An Internally Validated Nomogram for Predicting the Likelihood of Improvement of Clinical Global Impression in Patients with Lifelong Premature Ejaculation Treated with Dapoxetine

Hou

Gao

Zhang

et al. 2020

The Journal of Sexual Medicine

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Background: Although the introduction of dapoxetine has ushered in a new era in the treatment of premature ejaculation, many patients with lifelong premature ejaculation (LPE) exhibit an unimproved clinical global impression even after treatment with dapoxetine. Aim: To investigate independent predictors of the improvement of Clinical Global Impression (iCGI) in patients with LPE treated with dapoxetine and develop a nomogram to predict a patient's likelihood of achieving iCGI. Methods: Data of 243 patients with LPE diagnosed at Xijing Hospital (Xi'an, China) and Northwest Women's and Children's Hospital (Xi'an, China) from January 2019 to May 2020 were analyzed. Independent predictors of iCGI were identified, and a nomogram was developed using R software based on a multivariate logistic regression model. The predictive accuracy of the nomogram was measured using the area under the receiver operating characteristic curve. The nomogram was calibrated by comparing predictions with observations. Main Outcome Measures: The primary outcome was the patient-rated Clinical Global Impression of Change scale score after a 4-week course of dapoxetine treatment, which was collected via an online questionnaire. A Clinical Global Impression of Change score of !1 was defined as iCGI in this study. Results: Patients with LPE with at least a bachelor's degree, a self-reported intravaginal ejaculation latency time of >1 minute, and an International Index of Erectile Function question 5 score of !3 were independent factors associated with achieving iCGI, whereas a Premature Ejaculation Diagnostic Tool question 1 score of !2 was an independent factor negatively associated with achieving iCGI. The predictive accuracy of the nomogram, which was developed by integrating all variables with independent predictive significance, was 0.710 (95% confidence interval: 0.702e0.718). In addition, the calibration plot demonstrated excellent agreement between predictions and observations. Clinical Implications: If the predictive performance of our nomogram is further proven in multiple external validations, it can be used to select suitable patients for dapoxetine treatment, thereby reducing the number of patients discontinuing treatment. Strengths & Limitations: This study developed the first nomogram for predicting the likelihood of achieving iCGI in patients with LPE treated with dapoxetine. However, our nomogram was not externally validated using independent cohorts from other institutions. Conclusion: This study identified several independent predictors of iCGI in patients with LPE treated with dapoxetine. An effective nomogram was developed to predict their likelihood of achieving iCGI.

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“…The SEER Program supported by the National Cancer Institute is an authoritative source from 18 tumor registration centers containing approximately 30% of the United States population. 11 Specific clinical parameters and prognostic outcomes of patients with MRCC from 2010 to 2015 were collected from the SEER database using reference number 14622-Nov2017. The present research did not require local ethics approval or informed patient consent because SEER is a public database.…”

Section: Methodsmentioning

confidence: 99%

Construction and validation of a novel prognostic nomogram for patients with metastatic renal cell carcinoma: a SEER-based study

Zhou

et al. 2022

J Int Med Res

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Objective We aimed to establish and validate nomograms to evaluate overall survival (OS) and cancer-specific survival (CSS) in patients with metastatic renal cell carcinoma (MRCC). Methods Between 2010 and 2015, the clinical information of patients with MRCC was selected using the Surveillance, Epidemiology, and End Results database. Two nomograms were constructed based on Cox regression analysis, and their prediction accuracy was evaluated by concordance index (C-index), receiver operating characteristic (ROC) curve, and decision curve analysis (DCA). Results After propensity score matching, there were 568 patients with MRCC in the training group and 568 in the validation group. Multivariate analyses revealed that age, residence, pathology, T stage, N stage, surgery, and metastatic sites were independent prognostic factors for the OS and CSS of MRCC. The C-index and ROC curves indicated that the two nomograms of OS and CSS showed satisfactory discriminative power. Furthermore, DCA displayed that the nomograms achieved more clinical net benefit than the American Joint Committee on Cancer staging system. Conclusion We constructed and validated two effective prognostic nomograms for patients with MRCC that accurately predicted the probabilities of 1-, 2-, and 3-year OS and CSS.

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Construction and validation of a novel prognostic nomogram for patients with sarcomatoid renal cell carcinoma: a SEER-based study

Cited by 12 publications

References 22 publications

The first competing risk survival nomogram in patients with papillary renal cell carcinoma

The first competing risk survival nomogram in patients with papillary renal cell carcinoma

An Internally Validated Nomogram for Predicting the Likelihood of Improvement of Clinical Global Impression in Patients with Lifelong Premature Ejaculation Treated with Dapoxetine

Construction and validation of a novel prognostic nomogram for patients with metastatic renal cell carcinoma: a SEER-based study

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