Construction and validation of a prognostic risk model of angiogenesis factors in skin cutaneous melanoma

Abstract

Melanoma can secrete tumor angiogenesis factors, which is the essential factor for tumor growth and metastasis. However, there are few reports on the relationship between angiogenesis factors and prognosis risk in melanoma. This study aimed to develop a prognostic risk model of angiogenesis for melanoma. Forty-nine differentially expressed angiogenesis were identified from the TCGA database, which were mainly involved in PI3K/Akt pathway, focal adhesion, and MAPK signaling pathway. We then establish an eleven-gene signature. The model indicated a strong prognostic capability in both the discovery cohort and the validation cohort. Patients of smaller height (<170 cm) and lower weight (<80 kg) and those with advanced-stage and ulcerated melanoma had higher risk scores. The risk score was positively correlated with mutation load, homologous recombination defect, neoantigen load and chromosome instability. In addition, the high-risk group had a higher degree of immune cell infiltration, better response to immunotherapy and lower immune score. Therefore, these results indicate that the risk model is an effective method to predict the prognosis of melanoma.

Identification of neurotransmitters as novel biomarkers for the prognosis of colorectal cancer

“…More recently, it has become a prevalent problem in cancer research to establish prognostic pro les based on gene sets associated with speci c biological characteristics (Tang et al, 2022;Wen et al, 2023;Zou et al, 2022).It is commonly known that the ability of doctors to make decisions and carry out individualized treatment plans can be enhanced by precisely predicting prognosis by grouping patients into high-risk or low-risk groups based on dependable predictive criteria. Therefore, in this study, we comprehensively and systematically constructed NRGs-based signatures and further anatomized their practical clinical value to support the essential preclinical signi cance of the neurotransmitter eld in cancer research.…”

Construction of a risk model for predicting colorectal cancer prognosis and immunotherapy based on angiogenesis-related gene

“…The angiogenesis translation studies in CRC reveal that several angiogenesisrelated variables may be linked to prognosis [35]. Previous studies con rm that tumor angiogenesis is regulated by numerous genes with extremely complex interactions between these geness [15,36,37]. In the era of cancer precision medicine, multi-gene approaches can better describe tumor biology characteristics and guide clinical decision-making.…”

“…Accumulating of studies have strongly con rmed that the role of angiogenesis-related genes (ARGs) in the development of solid tumor, including CRCr [12][13][14]. Zou et al constructed a model based on ARGs classi cation in skin cutaneous melanoma (SKCM) to help stratify patients and predict prognosis and immunotherapy response [15]. To our knowledge, no studies have been reported on the prognostic features of CRC from the perspective of ARGs.…”