Construction and in vivo evaluation of a dual layered collagenous scaffold with a radial pore structure for repair of the diaphragm

Brouwer, Katrien M.; Daamen, Willeke F.; Lochem, Nicole van; Reijnen, Daphne; Wijnen, René; Kuppevelt, Toin H. Van

doi:10.1016/j.actbio.2013.03.003

Cited by 33 publications

(31 citation statements)

References 37 publications

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“…Conforming to our expectations, the radially oriented structure exhibited a predetermined 3-D shape, as well as suitable porosity and micromechanical properties. Brouwer and colleagues designed a twolayered collagenous scaffold with a radial pore structure for repair of the diaphragm, and found that cells infiltrate further into the center of the scaffold [24,39]. This is consistent with our results that BMSCs were recruited into the radially oriented scaffold.…”

Section: Discussionsupporting

confidence: 94%

“…Designing scaffolds with tissue-specific architecture is an effective way for osteochondral repair [21À23]. Meanwhile the threedimensional environment of the scaffolds such as pore size and orientation will affect the extracellular matrix deposition, as cells infiltrate into the scaffold will align with the pore and follow the channels arranged by the scaffold [24]. So it seems that current popular osteochondral scaffolds with random structures cannot facilitate the process of cell homing.…”

Section: Introductionmentioning

confidence: 99%

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Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing

et al. 2015

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing

et al. 2015

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“…They found that cells infiltrated further into the center of the scaffold. Besides, Brouwer and his colleagues also designed a scaffold with radial pore structure to repair the diaphragm defects, and reached the same conclusion [92, 93]. The in vivo experiments on rabbits confirmed that BMSCs could also be recruited into the radially-oriented scaffold with the assistance of SDF-1α.…”

Section: Applicationsmentioning

confidence: 80%

Delivery of stromal cell-derived factor 1α for in situ tissue regeneration

Zhao

Jin

et al. 2017

J Biol Eng

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In situ tissue regeneration approach aims to exploit the body’s own biological resources and reparative capability and recruit host cells by utilizing cell-instructive biomaterials. In order to immobilize and release bioactive factors in biomaterials, it is important to engineer the load effectiveness, release kinetics and cell recruiting capabilities of bioactive molecules by using suitable bonding strategies. Stromal cell-derived factor 1α (SDF-1α) is one of the most potent chemokines for stem cell recruitment, and SDF-1α-loaded scaffolds have been used for the regeneration of many types of tissues. This review summarizes the strategies to incorporate SDF-1α into scaffolds, including direct loading or adsorption, polyion complexes, specific heparin-mediated interaction and particulate system, which may be applied to the immobilization of other chemokines or growth factors. In addition, we discuss the application of these strategies in the regeneration of tissues such as blood vessel, myocardium, cartilage and bone.

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“…Unseeded scaffolds were implanted into a surgically created diaphragm defect in rats and explanted after 12 weeks. While new collagen deposition was more oriented in radial scaffolds with respect to round pores, cells and vessel migration within the scaffolds was similar between the two constructs [186]. …”

Section: Skeletal Musclementioning

confidence: 99%

Tissue Engineered Scaffolds for an Effective Healing and Regeneration: Reviewing Orthotopic Studies

Baiguera

Urbani

Gaudio

2014

BioMed Research International

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It is commonly stated that tissue engineering is the most promising approach to treat or replace failing tissues/organs. For this aim, a specific strategy should be planned including proper selection of biomaterials, fabrication techniques, cell lines, and signaling cues. A great effort has been pursued to develop suitable scaffolds for the restoration of a variety of tissues and a huge number of protocols ranging from in vitro to in vivo studies, the latter further differentiating into several procedures depending on the type of implantation (i.e., subcutaneous or orthotopic) and the model adopted (i.e., animal or human), have been developed. All together, the published reports demonstrate that the proposed tissue engineering approaches spread toward multiple directions. The critical review of this scenario might suggest, at the same time, that a limited number of studies gave a real improvement to the field, especially referring to in vivo investigations. In this regard, the present paper aims to review the results of in vivo tissue engineering experimentations, focusing on the role of the scaffold and its specificity with respect to the tissue to be regenerated, in order to verify whether an extracellular matrix-like device, as usually stated, could promote an expected positive outcome.

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Construction and in vivo evaluation of a dual layered collagenous scaffold with a radial pore structure for repair of the diaphragm

Cited by 33 publications

References 37 publications

Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing

Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing

Delivery of stromal cell-derived factor 1α for in situ tissue regeneration

Tissue Engineered Scaffolds for an Effective Healing and Regeneration: Reviewing Orthotopic Studies

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