Construction and First Tests of an &lt;italic&gt;in-beam&lt;/italic&gt; PET Demonstrator Dedicated to the Ballistic Control of Hadrontherapy Treatments With 65 MeV Protons

Binet, S.; Bongrand, A.; Busato, E.; Force, P.; Guicheney, C.; Insa, C.; Lambert, D.; Magne, M.; Martin, F. F.; Perrin, Herve; Podlyski, F.; Rozes, A.; Montarou, G.

doi:10.1109/trpms.2017.2780447

Cited by 12 publications

(8 citation statements)

References 21 publications

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“…Thus, these positrons are present only during the passage of the proton packets in the material (bursts). A common strategy adopted in in-beam PET studies is to reject events in bursts, which can be achieved with proper selection as described in [40] or [41]. In such cases, the contribution of positrons from prompt gammas to the measurement is negligible.…”

Section: Resultsmentioning

confidence: 99%

Use of short-lived positron emitters for in-beam and real-time β+ range monitoring in proton therapy

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Use of short-lived positron emitters for in-beam and real-time β+ range monitoring in proton therapy

et al. 2020

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“…D etector: Only the characteristics of the LAPD detector relevant for the studies presented in this paper are described. For a more complete description, the reader is referred to [1].…”

Section: E Xperimental Setup Data and Event Selectionmentioning

confidence: 99%

“…In the following, the β + activity will be written as 1 a a   (1) where  1 is the activity of the source used in step 1.a and  is the scaling parameter.…”

Section: Scaling O F Yields With Activity (Step 1b)mentioning

confidence: 99%

Detection limit of a lutetium based non-paralizable PET-like detector

Busato¹,

Roux²

2020

Int J Phys Res Appl

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The eff ect of the intrinsic lutetium radioactivity on the detection performances of a LYSO based in-beam PET-like prototype used for quality control of hadrontherapy treatments is studied. This radioactivity leads to a background that degrades the measurement of the β + signal. In particular, it prevents the measurement of faint signals originating from low activity β + sources. This paper presents a method to estimate the minimum β + activity that can be measured for any acquisition time taking into account the non-extensible dead time of the detector. This method is illustrated with experimental data collected with the in-beam PET-like prototype. The results presented in this paper are therefore specifi c to this detector. The method can however be applied in other contexts, either to other lutetium based PET detectors or even to non-PET detectors aff ected by lutetium radioactivity. The dead time correction formalism can also be used generally to scale signal and background yields in any non-paralizable detector, even those in which the background is not due to the presence of intrinsic radioactivity. I A non-paralizable detector is a detector with a non-extensible dead time.

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“…Based on the acquisition of back to back photons from the β+ annihilation, it is possible to reconstruct the position of the β+ emitters produced by proton interactions with the patient tissue during irradiation. Different data acquisition modalities are off-beam, in-beam and in-room PET [4][5][6][7][8][9][10][11][12][13][14]. PET monitoring is conventionally done by acquiring data during or after irradiation, and comparing the data with reference distributions, either from Monte Carlo (MC) or from previous treatment sessions [15,18].…”

Section: Introductionmentioning

confidence: 99%

Monitoring Proton Therapy Through in-Beam PET: An Experimental Phantom Study

Topi

Kraan

Krzempek

et al. 2020

IEEE Trans. Radiat. Plasma Med. Sci.

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In this work, we investigate the use of a PET system to monitor the proton therapy. The monitoring procedure is based on the comparison between the β+activity generated in the irradiated volume during the treatment, with the β+activity distribution obtained with Monte Carlo simulation. The dedicated PET system is a dual head detection system; each head is composed of nine scintillating LYSO crystal matrices read out independently with a custom modularized acquisition system. Our experimental data were acquired at the Cyclotron Centre Bronowice, Institute Nuclear Physics in Krakow, Poland and were simulated with the FLUKA Monte Carlo code. Homogeneous and heterogeneous plastic phantoms were irradiated with monoenergetic 130-MeV protons. The capabilities of our PET system to distinguish different irradiated materials were investigated, and the proton pencil beams were used as probes. Our focus was to analyze the activity width and the total activity event number in several cases. Irradiations were performed using either single pencil beams one at a time, or two pencil beams during the same data taking. The comparison of 1D activity profile for experimental data and MC simulation were always in good agreement showing that, the treatment quality assessment in proton therapy can be based on β+ activity measurements.

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Construction and First Tests of an <italic>in-beam</italic> PET Demonstrator Dedicated to the Ballistic Control of Hadrontherapy Treatments With 65 MeV Protons

Cited by 12 publications

References 21 publications

Use of short-lived positron emitters for in-beam and real-time β+ range monitoring in proton therapy

Use of short-lived positron emitters for in-beam and real-time β+ range monitoring in proton therapy

Detection limit of a lutetium based non-paralizable PET-like detector

Monitoring Proton Therapy Through in-Beam PET: An Experimental Phantom Study

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