Construction and evaluation of tumor nucleus-targeting nanocomposite for cancer dual-mode imaging – Guiding photodynamic therapy/photothermal therapy

Zhou, Jie; Wang, Qiaolei; Geng, Shizhen; Lou, Rui; Yin, Qingsong; Ye, Weiran

doi:10.1016/j.msec.2019.04.088

Cited by 30 publications

(14 citation statements)

References 29 publications

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“…These multifunctional nanoplatforms can directly release ROS and heat in the nucleus to enhance PDT/PTT. [230] Under NIR irradiation, the nucleus targeting nanoplatform showed a significant inhibitory effect on tumor growth, and the damage to DNA was very high (59.6%). [230] To overcome the low cell uptake of Au 25 (Capt) 18 , a polyacrylamide-encapsulated Au 25 (Capt) 18 nanocomposite (PAAm-Au 25 (Capt) 18 ) was synthesized, which showed improved biocompatibility, cellular uptake, and targeting potential.…”

Section: Metal Nanoclusters As Photoagentsmentioning

confidence: 98%

“…[230] Under NIR irradiation, the nucleus targeting nanoplatform showed a significant inhibitory effect on tumor growth, and the damage to DNA was very high (59.6%). [230] To overcome the low cell uptake of Au 25 (Capt) 18 , a polyacrylamide-encapsulated Au 25 (Capt) 18 nanocomposite (PAAm-Au 25 (Capt) 18 ) was synthesized, which showed improved biocompatibility, cellular uptake, and targeting potential. [231] In addition, photo-irradiation experiments on HeLa cancer cells exhibited promising TP-PDT efficacy, showing the potential of PAAm-Au 25 (Capt) 18 in PDT.…”

Section: Metal Nanoclusters As Photoagentsmentioning

confidence: 98%

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Engineering Metal Nanoclusters for Targeted Therapeutics: From Targeting Strategies to Therapeutic Applications

Lin

Goswami

Xue

et al. 2021

Adv Funct Materials

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Metal nanoclusters (NCs) have recently attracted great interest in biomedical applications due to their ultrasmall size, good biocompatibility, and unique molecule-like physical and chemical properties. Metal NCs can be rationally designed and integrated with various targeting moieties to achieve unique physicochemical properties and functions. For therapeutic applications, these multifunctional surface-modified NCs can provide distinctive advantages over native metal NCs, such as improved therapeutic effects and reduced side effects. In this review, the design principles of targeting strategies for metal NCs and their composites, including passive and active targeting, and physical and chemical targeting are first discussed. The authors then focus on the recent achievements in the application of metal NCs in targeted therapeutics, including chemotherapy, phototherapy, and radiotherapy. Finally, the authors' perspectives on the challenges and opportunities of developing metal NCs in targeted therapeutics, further paving their way for potential clinical applications are provided.

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Section: Metal Nanoclusters As Photoagentsmentioning

confidence: 98%

Section: Metal Nanoclusters As Photoagentsmentioning

confidence: 98%

Engineering Metal Nanoclusters for Targeted Therapeutics: From Targeting Strategies to Therapeutic Applications

Lin

Goswami

Xue

et al. 2021

Adv Funct Materials

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“…Targeting subcellular organelles, including the nucleus, mitochondria, and lysosomes, has been shown to significantly enhance phototherapeutic efficacy 167 . Zhou et al developed a nucleus-targeting nanoplatform for dual PTT-PDT that resulted in high DNA damage 168 . Targeting of the mitochondria has also garnered much attention due to their important role in cell apoptosis and tumorigenesis 169 , high abundance throughout the cytoplasm, ease of access compared to the nucleus 170 , and hypersensitivity to heat shock and ROS-induced damage 171 .…”

Section: Mri-guided Nanoparticles For Combination Therapymentioning

confidence: 99%

MRI-traceable theranostic nanoparticles for targeted cancer treatment

Anani¹,

Rahmati²,

Nayer³

et al. 2021

Theranostics

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Current cancer therapies, including chemotherapy and radiotherapy, are imprecise, non-specific, and are often administered at high dosages - resulting in side effects that severely impact the patient's overall well-being. A variety of multifunctional, cancer-targeted nanotheranostic systems that integrate therapy, imaging, and tumor targeting functionalities in a single platform have been developed to overcome the shortcomings of traditional drugs. Among the imaging modalities used, magnetic resonance imaging (MRI) provides high resolution imaging of structures deep within the body and, in combination with other imaging modalities, provides complementary diagnostic information for more accurate identification of tumor characteristics and precise guidance of anti-cancer therapy. This review article presents a comprehensive assessment of nanotheranostic systems that combine MRI-based imaging (T1 MRI, T2 MRI, and multimodal imaging) with therapy (chemo-, thermal-, gene- and combination therapy), connecting a range of topics including hybrid treatment options ( e.g. combined chemo-gene therapy), unique MRI-based imaging ( e.g. combined T1-T2 imaging, triple and quadruple multimodal imaging), novel targeting strategies ( e.g. dual magnetic-active targeting and nanoparticles carrying multiple ligands), and tumor microenvironment-responsive drug release ( e.g. redox and pH-responsive nanomaterials). With a special focus on systems that have been tested in vivo , this review is an essential summary of the most advanced developments in this rapidly evolving field.

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“…A nucleus‐targeting strategy is widely used in non‐invasive photodynamic therapy (PDT). [ 66 ] Liu and co‐workers fabricated a metallic oxide nanoenzyme derived from Mn‐MOF for enhancing nucleus‐targeted PDT efficacy. The Mn 3 O 4 NP was obtained from calcinated Mn‐MOF under 300 °C for 5 h. The Mn 3 O 4 NP possessed a CAT‐like ability to catalyze the decomposition of hydrogen peroxide to water and oxygen, raising the oxygen level to achieve an enhanced PDT performance.…”

Section: Subcellular Organelles‐targeted Mof Therapymentioning

confidence: 99%

Biomedical Applications of Metal–Organic Frameworks at the Subcellular Level

Xue

Liu

Yong

et al. 2021

Advanced NanoBiomed Research

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Organelles, or subcellular structures, are the fundamental functional units in almost all eukaryotic cells. Consequently, they play a critical role in the development of various biomedical applications, such as targeted drug delivery, biosensing, imaging, and biomimetics. Many efforts are devoted to developing nanosystems that can target specific organelles in a controlled manner. A series of nanomaterials with high porosity, stability, and easy‐to‐tailor properties, named metal–organic frameworks (MOFs), have shown to be a promising new class of nanocarriers and bioprotective exoskeletons for biomedical and biocatalytical platforms at the subcellular level. Herein, the recent state‐of‐the‐art progress of MOF nanomaterials for bioapplications at the subcellular level is highlighted. In the first section, MOF‐derived biomimetics organelles and subcellular structures are highlighted. Then, the strategies of organelle‐targeted MOF therapy and biosensing are illustrated. Next, MOF‐based biopreservation of organelles is introduced. Finally, a personal perspective about the challenges and future innovative designs is discussed.

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Construction and evaluation of tumor nucleus-targeting nanocomposite for cancer dual-mode imaging – Guiding photodynamic therapy/photothermal therapy

Cited by 30 publications

References 29 publications

Engineering Metal Nanoclusters for Targeted Therapeutics: From Targeting Strategies to Therapeutic Applications

Engineering Metal Nanoclusters for Targeted Therapeutics: From Targeting Strategies to Therapeutic Applications

MRI-traceable theranostic nanoparticles for targeted cancer treatment

Biomedical Applications of Metal–Organic Frameworks at the Subcellular Level

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