2017
DOI: 10.4172/2161-0517.1000161
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Construction and Detection of Recombinant Adeno-Associated Virus Co- Expressing PRRSV GP5, M Proteins and shRNA

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is a severe threat to the swine industry and has caused heavy economic losses worldwide. The currently used inactivated and attenuated virus vaccines have several shortcomings, such as unsafety and low protection rate, so it is urgent to develop a new vaccine. To explore and develop a novel vaccine against PRRSV, a bi-functional recombinant adeno-associated virus, expressing ORF5 and ORF6 proteins as well as a short interfering RNA (shRNA) against ORF… Show more

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